Ying-Jie Li1, Wen Zhang1, Hui Xia1, Bao-Shi Zhang1, Ping Chen1, Yun-Long Zhao1, Jie Li2. 1. Department of Cardio-thoracic Surgery, First Affiliated Hospital of Chinese PLA General Hospital, Beijing, 100048, China. 2. Thoracic Surgeon, Department of Thoracic Surgery, The Chinese PLA General Hospital, Beijing, 100853, China.
Abstract
AIM: Although, miR-218 has been implicated in epithelial-to-mesenchymal transition process, the detailed mechanisms of miR-218 involvement in epithelial-to-mesenchymal transition in human lung adenocarcinoma cell are still unclear. MATERIALS & METHODS: miR-218 function assays and its target gene analysis were performed. RESULTS: miR-218 suppresses human lung adenocarcinoma cell migration and invasion and inhibits its target gene, Ecop and Robo1 expression, which subsequently suppresses NF-κB activity and its downstream targets. CONCLUSION: miR-218 inhibits human lung adenocarcinoma cell migration and invasion via the suppression of Ecop and Robo1 expression, thus suggesting that miR-218 could serve as a potential therapeutic target.
AIM: Although, miR-218 has been implicated in epithelial-to-mesenchymal transition process, the detailed mechanisms of miR-218 involvement in epithelial-to-mesenchymal transition in humanlung adenocarcinoma cell are still unclear. MATERIALS & METHODS:miR-218 function assays and its target gene analysis were performed. RESULTS:miR-218 suppresses humanlung adenocarcinoma cell migration and invasion and inhibits its target gene, Ecop and Robo1 expression, which subsequently suppresses NF-κB activity and its downstream targets. CONCLUSION:miR-218 inhibits humanlung adenocarcinoma cell migration and invasion via the suppression of Ecop and Robo1 expression, thus suggesting that miR-218 could serve as a potential therapeutic target.