| Literature DB >> 2893655 |
E B De Souza1, P J Whitehouse, S E Folstein, D L Price, W W Vale.
Abstract
Corticotropin-releasing hormone-like immunoreactivity (CRH-IR) was measured in control and Huntington's disease brain tissues obtained postmortem. The concentration of CRH-IR was markedly decreased in the caudate/putamen in Huntington's disease; the concentration of somatostatin-like immunoreactivity measured in the same extracts was significantly increased in the caudate/putamen in Huntington's disease compared with the control group. In contrast to previously reported decreases in CRH-IR in the cerebral cortex in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy, no significant differences were observed in the concentrations of CRH-IR between controls and Huntington's disease in frontal, parietal, temporal, occipital and cingulate cortex and in globus pallidus.Entities:
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Year: 1987 PMID： 2893655 DOI： 10.1016/0006-8993(87)91651-9
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252