Robert Cordesmeyer1, Henning Schliephake2, Philipp Kauffmann2, Markus Tröltzsch2, Rainer Laskawi3, Philipp Ströbel4, Felix Bremmer4. 1. Department of Oral and Maxillofacial Surgery (Head: Prof. Dr. Dr. Henning Schliephake), Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany. Electronic address: robert.cordesmeyer@med.uni-goettingen.de. 2. Department of Oral and Maxillofacial Surgery (Head: Prof. Dr. Dr. Henning Schliephake), Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany. 3. Department of Otolaryngology-Head and Neck Surgery (Head: Prof. Dr. Martin Canis), Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany. 4. Department of Pathology (Head: Prof. Dr. Philipp Ströbel), Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.
Abstract
PURPOSE: Adenoid cystic carcinomas are rare malignant tumors of the salivary glands. They are characterized by a high rate of local recurrence, late distant metastasis and a poor disease-free survival. In this study, we analyzed a series of 61 patients who were all treated at the University of Göttingen over a period of 21.0 years. MATERIALS AND METHODS: In all 61 patients with salivary adenoid cystic carcinoma, clinical data, demographic data, risk factors, tumor location, tumor stage, status of surgical margin, surgical treatment, postoperative radiotherapy and follow-up interval were assessed. RESULTS: The overall survival (OS) and the disease-free survival (DFS) of patients who underwent surgery and those who underwent combined surgery with radiotherapy showed no significant differences. Neither did the T-stage (T1/T2 vs. T3/T4) show significant differences in OS and DFS. Only the status of the surgical margin was significantly associated with a longer OS and a longer DFS. CONCLUSION: The present results confirm that the radical surgical resection with clear tumor-free margins is the most important predictor for a longer survival. Adjuvant radiotherapy should be discussed from case to case, but should not be seen as an absolute prognostic factor for OS.
PURPOSE:Adenoid cystic carcinomas are rare malignant tumors of the salivary glands. They are characterized by a high rate of local recurrence, late distant metastasis and a poor disease-free survival. In this study, we analyzed a series of 61 patients who were all treated at the University of Göttingen over a period of 21.0 years. MATERIALS AND METHODS: In all 61 patients with salivary adenoid cystic carcinoma, clinical data, demographic data, risk factors, tumor location, tumor stage, status of surgical margin, surgical treatment, postoperative radiotherapy and follow-up interval were assessed. RESULTS: The overall survival (OS) and the disease-free survival (DFS) of patients who underwent surgery and those who underwent combined surgery with radiotherapy showed no significant differences. Neither did the T-stage (T1/T2 vs. T3/T4) show significant differences in OS and DFS. Only the status of the surgical margin was significantly associated with a longer OS and a longer DFS. CONCLUSION: The present results confirm that the radical surgical resection with clear tumor-free margins is the most important predictor for a longer survival. Adjuvant radiotherapy should be discussed from case to case, but should not be seen as an absolute prognostic factor for OS.