Victor M Salinas-Torres1, Rafael A Salinas-Torres2, Ricardo M Cerda-Flores3, Laura E Martínez-de-Villarreal4. 1. Universidad Autónoma de Nuevo León, Departamento de Genética, Facultad de Medicina y Hospital Universitario José Eleuterio González, Ave. Madero y Gonzalitos S/N Col. Mitras Centro, Monterrey, Nuevo León CP 64460, Mexico.; Instituto de Servicios de Salud Pública en el Estado de Baja California, Departamento de Genética, Hospital General Tijuana, Av Centenario 10851, Zona Rio, Tijuana, Baja California CP 22320, Mexico.. Electronic address: vm_salinas7@hotmail.com. 2. Instituto de Servicios de Salud Pública en el Estado de Baja California, Departamento de Genética, Hospital General Tijuana, Av Centenario 10851, Zona Rio, Tijuana, Baja California CP 22320, Mexico.; Instituto Tecnológico de Tijuana, Departamento de Sistemas y Computación, Calzada del Tecnológico S/N Fracc. Tomas Aquino, Tijuana, Baja California CP 22414, Mexico.. Electronic address: rafaelsalinas.itt@gmail.com. 3. Universidad Autónoma de Nuevo León, Facultad de Enfermería, Dr. José Eleuterio González 1500, Mitras Norte, Monterrey, Nuevo León CP 64460, Mexico.. Electronic address: ricardocerda_mx@yahoo.com.mx. 4. Universidad Autónoma de Nuevo León, Departamento de Genética, Facultad de Medicina y Hospital Universitario José Eleuterio González, Ave. Madero y Gonzalitos S/N Col. Mitras Centro, Monterrey, Nuevo León CP 64460, Mexico.. Electronic address: laelmar@yahoo.com.mx.
Abstract
PURPOSE: To evaluate the occurrence of gastroschisis attributable to familial factors in a Mexican population-based setting. METHODS: A descriptive study was performed among gastroschisis cases born from 2010 through 2016 at Tijuana General Hospital (Baja California, Mexico) to generate multigenerational pedigrees. RESULTS: There were 87 gastroschisis cases from 57,217 live births. Six probands (6.9%) had another affected family member. Two half-siblings, a set of monozygotic twins, a mother-and-daughter occurrence, a distant paternal cousin and a distant maternal uncle were identified. Sibling recurrence was 5.5%. From 174 males and 153 females studied (n=327, involving 180 nuclear families), sex-dependent influence analysis evidenced an increased susceptibility to gastroschisis in males (3.2%) compared to females (1.8%) with an overall of 2.5% adjusted for proband. CONCLUSIONS: Our results provide a greater liability attributable to familial factors on gastroschisis. In spite of the predominant sporadic occurrence, underlying genetic susceptibility and environmental influences point to a complex interplay between genes and environmental factors in gastroschisis. LEVEL OF EVIDENCE: Level IV.
PURPOSE: To evaluate the occurrence of gastroschisis attributable to familial factors in a Mexican population-based setting. METHODS: A descriptive study was performed among gastroschisis cases born from 2010 through 2016 at Tijuana General Hospital (Baja California, Mexico) to generate multigenerational pedigrees. RESULTS: There were 87 gastroschisis cases from 57,217 live births. Six probands (6.9%) had another affected family member. Two half-siblings, a set of monozygotic twins, a mother-and-daughter occurrence, a distant paternal cousin and a distant maternal uncle were identified. Sibling recurrence was 5.5%. From 174 males and 153 females studied (n=327, involving 180 nuclear families), sex-dependent influence analysis evidenced an increased susceptibility to gastroschisis in males (3.2%) compared to females (1.8%) with an overall of 2.5% adjusted for proband. CONCLUSIONS: Our results provide a greater liability attributable to familial factors on gastroschisis. In spite of the predominant sporadic occurrence, underlying genetic susceptibility and environmental influences point to a complex interplay between genes and environmental factors in gastroschisis. LEVEL OF EVIDENCE: Level IV.
Authors: Victor M Salinas-Torres; Rafael A Salinas-Torres; Ricardo M Cerda-Flores; Hugo L Gallardo-Blanco; Laura E Martínez-de-Villarreal Journal: Pediatr Surg Int Date: 2018-08-09 Impact factor: 1.827
Authors: Victor M Salinas-Torres; Rafael A Salinas-Torres; Ricardo M Cerda-Flores; Laura E Martínez-de-Villarreal Journal: Pediatr Surg Int Date: 2018-03-17 Impact factor: 1.827
Authors: Victor M Salinas-Torres; Rafael A Salinas-Torres; Ricardo M Cerda-Flores; Laura E Martínez-de-Villarreal Journal: Pediatr Surg Int Date: 2018-01-15 Impact factor: 1.827
Authors: Víctor M Salinas-Torres; Hugo L Gallardo-Blanco; Rafael A Salinas-Torres; Ricardo M Cerda-Flores; José J Lugo-Trampe; Daniel Z Villarreal-Martínez; Laura E Martínez de Villarreal Journal: Int J Mol Sci Date: 2019-05-09 Impact factor: 5.923
Authors: Víctor M Salinas-Torres; Hugo L Gallardo-Blanco; Rafael A Salinas-Torres; Ricardo M Cerda-Flores; José J Lugo-Trampe; Daniel Z Villarreal-Martínez; Marisol Ibarra-Ramírez; Laura E Martínez de Villarreal Journal: Mol Genet Genomic Med Date: 2020-03-12 Impact factor: 2.183
Authors: Elisabeth Pechriggl; Michael Blumer; R Shane Tubbs; Łukasz Olewnik; Marko Konschake; René Fortélny; Hannes Stofferin; Hanne Rose Honis; Sara Quinones; Eva Maranillo; José Sanudo Journal: Front Surg Date: 2022-07-07