Carlos Martín de Vicente1, Inés de Mir Messa2, Sandra Rovira Amigo2, Alba Torrent Vernetta2, Silvia Gartner2, Ignacio Iglesias Serrano2, Antonio Carrascosa Lezcano3, Antonio Moreno Galdó4. 1. Sección de Neumología Pediátrica, Hospital Miguel Servet, Zaragoza, España. 2. Sección de Alergia Pediátrica, Neumología Pediátrica y Fibrosis quística, Hospital Universitario Vall d'Hebron, Barcelona, España. 3. Sección de Endocrinología Pediátrica, Hospital Universitario Vall d'Hebron, Barcelona, España; Departamento de Pediatría, Obstetricia y Ginecología, y Medicina Preventiva y Salud Pública, Universitat Autònoma de Barcelona, Barcelona, España; CIBER of Rare Diseases (CIBERER), ISCIII, Madrid, España. 4. Sección de Alergia Pediátrica, Neumología Pediátrica y Fibrosis quística, Hospital Universitario Vall d'Hebron, Barcelona, España; Departamento de Pediatría, Obstetricia y Ginecología, y Medicina Preventiva y Salud Pública, Universitat Autònoma de Barcelona, Barcelona, España. Electronic address: amoreno@vhebron.net.
Abstract
INTRODUCTION: Recent publication of multi-ethnic spirometry reference equations for subjects aged from 3-95 years aim to avoid age-related discontinuities and provide a worldwide standard for interpreting spirometric test results. OBJECTIVES: To assess the agreement of the Global Lung Function Initiative (GLI-2012) and All ages (FEV0.5) reference equations with the Spanish preschool lung function data. To verify the appropriateness of these reference values for clinical use in Spanish preschool children. METHODS: Spirometric measurements were obtained from children aged 3 to 6 years attending 10 randomly selected schools in Barcelona (Spain). Stanojevic's quality control criteria were applied. Z-scores were calculated for the spirometry outcomes based on the GLI equations. If the z-score (mean) of each parameter was close to 0, with a maximum variance of ± 0.5 from the mean and a standard deviation of 1, the GLI-2012 equations would be applicable in our population. RESULTS: Of 543 children recruited, 405 (74.6%) were 'healthy', and of these, 380 were Caucasians. Of these 380, 81.6% (169 females, 141 males) performed technically acceptable and reproducible maneuvers to assess FEVt, and 69.5% achieved a clear end-expiratory plateau. Z-scores for FVC, FEV1, FEV1/FVC, FEV0.75, FEV0.75/FVC, FEV0.5, FEF75 and FEF25-75 all fell within ± 0.5, except for FEV1/FVC (0.53 z-scores). CONCLUSIONS: GLI equations are appropriate for Spanish preschool children. These data provide further evidence to support widespread application of the GLI reference equations.
INTRODUCTION: Recent publication of multi-ethnic spirometry reference equations for subjects aged from 3-95 years aim to avoid age-related discontinuities and provide a worldwide standard for interpreting spirometric test results. OBJECTIVES: To assess the agreement of the Global Lung Function Initiative (GLI-2012) and All ages (FEV0.5) reference equations with the Spanish preschool lung function data. To verify the appropriateness of these reference values for clinical use in Spanish preschool children. METHODS: Spirometric measurements were obtained from children aged 3 to 6 years attending 10 randomly selected schools in Barcelona (Spain). Stanojevic's quality control criteria were applied. Z-scores were calculated for the spirometry outcomes based on the GLI equations. If the z-score (mean) of each parameter was close to 0, with a maximum variance of ± 0.5 from the mean and a standard deviation of 1, the GLI-2012 equations would be applicable in our population. RESULTS: Of 543 children recruited, 405 (74.6%) were 'healthy', and of these, 380 were Caucasians. Of these 380, 81.6% (169 females, 141 males) performed technically acceptable and reproducible maneuvers to assess FEVt, and 69.5% achieved a clear end-expiratory plateau. Z-scores for FVC, FEV1, FEV1/FVC, FEV0.75, FEV0.75/FVC, FEV0.5, FEF75 and FEF25-75 all fell within ± 0.5, except for FEV1/FVC (0.53 z-scores). CONCLUSIONS:GLI equations are appropriate for Spanish preschool children. These data provide further evidence to support widespread application of the GLI reference equations.
Keywords:
Children; Espirometría; Global Lung Function Initiative; Niños; Preescolares; Preschool children; Reference values; Spirometry; Valores de referencia
Authors: Rebeca Mozun; Cristina Ardura-Garcia; Eva S L Pedersen; Jakob Usemann; Florian Singer; Philipp Latzin; Alexander Moeller; Claudia E Kuehni Journal: ERJ Open Res Date: 2022-04-19
Authors: Segundo Rite; Carlos Martín de Vicente; Juan P García-Iñiguez; María L Couce; María P Samper; Alicia Montaner; Carmen Ruiz de la Cuesta Journal: Front Pediatr Date: 2022-02-04 Impact factor: 3.418