Kym J Guelfi1, Ming Jing Ong1, Shaofu Li2, Karen E Wallman1, Dorota A Doherty2, Paul A Fournier1, John P Newnham3, Jeffrey A Keelan4. 1. School of Human Sciences, Faculty of Science, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia. 2. Division of Obstetrics & Gynaecology, School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia. 3. Division of Obstetrics & Gynaecology, School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia; Department of Maternal Fetal Medicine, King Edward Memorial Hospital, 374 Bagot Rd, Subiaco, WA 6008, Australia. 4. Division of Obstetrics & Gynaecology, School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia. Electronic address: jeff.keelan@uwa.edu.au.
Abstract
BACKGROUND: Cytokines produced by adipose and placental tissues (adipokines) have been implicated in the development of gestational diabetes mellitus (GDM). There is, however, limited research regarding the relationship between advancing pregnancy, maternal adipokine profile, insulin resistance and the development of GDM. Furthermore, no studies have investigated these parameters in women with a history of GDM who are at the highest risk of recurrence. This study examined the circulating concentrations of a number of adipokines associated with insulin resistance at two points in pregnancy, and determined whether they were altered in women who developed GDM. METHODS: Non-diabetic women with a history of GDM in a previous pregnancy (n=123) had blood drawn at 14 and 28weeks of pregnancy for GDM diagnosis, together with assessment of a range of adipokine concentrations by multiplex assay (fatty acid-binding protein 4 [FABP4], leptin, chemerin, adiponectin and resistin). RESULTS: With advancing pregnancy, maternal adiponectin concentrations decreased, while leptin and resistin levels increased (p<0.05). In women who developed GDM at 28weeks of pregnancy (42%), fasting and postprandial glucose levels were already significantly elevated by 14weeks (p<0.05), while adiponectin concentrations were lower (p<0.05). Adiponectin remained lower at the time of GDM diagnosis (p<0.05), while the other adipokines were similar between groups at each timepoint. CONCLUSION: Maternal glucose and adipokine profile is altered early in pregnancy in women with a history of GDM who subsequently develop recurrent disease.
BACKGROUND: Cytokines produced by adipose and placental tissues (adipokines) have been implicated in the development of gestational diabetes mellitus (GDM). There is, however, limited research regarding the relationship between advancing pregnancy, maternal adipokine profile, insulin resistance and the development of GDM. Furthermore, no studies have investigated these parameters in women with a history of GDM who are at the highest risk of recurrence. This study examined the circulating concentrations of a number of adipokines associated with insulin resistance at two points in pregnancy, and determined whether they were altered in women who developed GDM. METHODS:Non-diabeticwomen with a history of GDM in a previous pregnancy (n=123) had blood drawn at 14 and 28weeks of pregnancy for GDM diagnosis, together with assessment of a range of adipokine concentrations by multiplex assay (fatty acid-binding protein 4 [FABP4], leptin, chemerin, adiponectin and resistin). RESULTS: With advancing pregnancy, maternal adiponectin concentrations decreased, while leptin and resistin levels increased (p<0.05). In women who developed GDM at 28weeks of pregnancy (42%), fasting and postprandial glucose levels were already significantly elevated by 14weeks (p<0.05), while adiponectin concentrations were lower (p<0.05). Adiponectin remained lower at the time of GDM diagnosis (p<0.05), while the other adipokines were similar between groups at each timepoint. CONCLUSION: Maternal glucose and adipokine profile is altered early in pregnancy in women with a history of GDM who subsequently develop recurrent disease.
Authors: Yi Ding; Mariëlle C Haks; Gabriel Forn-Cuní; Junling He; Natalia Nowik; Amy C Harms; Thomas Hankemeier; Muhamed N H Eeza; Jörg Matysik; A Alia; Herman P Spaink Journal: Cell Biosci Date: 2021-07-07 Impact factor: 7.133
Authors: Ellen C Francis; Mengying Li; Stefanie N Hinkle; Yaqi Cao; Jinbo Chen; Jing Wu; Yeyi Zhu; Haiming Cao; Karen Kemper; Lior Rennert; Joel Williams; Michael Y Tsai; Liwei Chen; Cuilin Zhang Journal: BMJ Open Diabetes Res Care Date: 2020-07