Literature DB >> 28934922

Inhibition of phosphatidylinositide 3-kinase impairs the benzyl isothiocyanate-induced accumulation of autophagic molecules and Nrf2 in human colon cancer cells.

Xiaoyang Liu1,2, Naomi Abe-Kanoh1,3, Yujia Liu1,2, Beiwei Zhu2, Shintaro Munemasa1, Toshiyuki Nakamura1, Yoshiyuki Murata1, Yoshimasa Nakamura1.   

Abstract

The regulating role of phosphatidylinositide 3-kinase (PI3K) in benzyl isothiocyanate (BITC)-induced Nrf2 activation, contributing to the inducible expression of cytoprotective genes, was investigated. BITC significantly enhanced the accumulation of Nrf2 as well as autophagic molecules in human colorectal cancer HCT-116 cells. Experiments using a PI3K-specific inhibitor suggested that PI3K plays the key role in the non-canonical Nrf2 activation by BITC.

Entities:  

Keywords:  Keap1; Nrf2; autophagy; benzyl isothiocyanate; phosphatidylinositide 3-kinase

Mesh：

Substances：

Year:  2017        PMID： 28934922     DOI： 10.1080/09168451.2017.1374830

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  3 in total

1.  Benzyl Isothiocyanate-Induced Cytotoxicity via the Inhibition of Autophagy and Lysosomal Function in AGS Cells.

Authors:  Wah Wah Po; Won Seok Choi; Tin Myo Khing; Ji-Yun Lee; Jong Hyuk Lee; Joon Seok Bang; Young Sil Min; Ji Hoon Jeong; Uy Dong Sohn
Journal:  Biomol Ther (Seoul)       Date:  2022-07-01       Impact factor: 4.231

2.  Nuclear Factor Erythroid 2-Related Factor 2 in Regulating Cancer Metabolism.

Authors:  Katarína Smolková; Edit Mikó; Tünde Kovács; Alberto Leguina-Ruzzi; Adrienn Sipos; Péter Bai
Journal:  Antioxid Redox Signal       Date:  2020-03-18       Impact factor: 8.401

Review 3.  Physiological relevance of covalent protein modification by dietary isothiocyanates.

Authors:  Toshiyuki Nakamura; Naomi Abe-Kanoh; Yoshimasa Nakamura
Journal:  J Clin Biochem Nutr       Date:  2017-12-12       Impact factor: 3.114
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.