Literature DB >> 2893326

Antinociceptive and 'neurotoxic' actions of somatostatin in rat spinal cord after intrathecal administration.

Peter Mollenholt1, Claes Post, Narinder Rawal, Jacob Freedman, Tomas Hökfelt, Ivar Paulsson.   

Abstract

In the present investigation, the antinociceptive effect of somatostatin (SST) was assessed after intrathecal injection in rats. It was found that the peptide caused antinociception, hind limb paralysis and neuronal damage of the spinal cord in a dose-dependent manner. The threshold dose for antinociception was lower (approximately 10 micrograms) than that (approximately 30 micrograms) giving rise to chronic motor impairment associated with necrotic changes and loss of an immunohistochemical marker for motoneurons in the spinal cord. It is concluded that the 'neurotoxic' potential of SST should be considered in further clinical trials.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 2893326     DOI： 10.1016/0304-3959(88)90028-0

Source DB:  PubMed          Journal:  Pain        ISSN： 0304-3959            Impact factor:   6.961


  11 in total

Review 1.  The epidural and intrathecal administration of somatotrophin-release inhibiting factor: native and synthetic analogues.

Authors:  D P Beltrutti; S Moessinger; G Varrassi
Journal:  Curr Rev Pain       Date:  2000

2.  Distribution of somatostatin-immunoreactive nerve fibres in Peyer's patches.

Authors:  E Fehér; M Fodor; G Burnstock
Journal:  Gut       Date:  1992-09       Impact factor: 23.059

3.  Effects of octreotide on responses to colorectal distension in the rat.

Authors:  X Su; M B Burton; G F Gebhart
Journal:  Gut       Date:  2001-05       Impact factor: 23.059

4.  Immunohistochemical and behavioral analysis of spinal lesions induced by a substance P antagonist and protection by thyrotropin releasing hormone.

Authors:  J Freedman; T Hökfelt; C Post; E Brodin; E Sundström; G Jonsson; L Terenius; S Leander; J A Fischer; A Verhofstad
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

5.  Involvement of spinal somatostatin receptor SST(2A) in inflammation-induced thermal hyperalgesia: ultrastructural and behavioral studies in rats.

Authors:  Jun Zhao; Jiang-Yuan Hu; Yu-Qiu Zhang; Zhi-Qi Zhao
Journal:  Neurochem Res       Date:  2008-05-02       Impact factor: 3.996

6.  Effects of somatostatin on the responses of rostrally projecting spinal dorsal horn neurons to noxious stimuli in cats.

Authors:  Sung Jun Jung; Su-Hyun Jo; Sanghyuck Lee; Eunhui Oh; Min-Seok Kim; Woo Dong Nam; Seog Bae Oh
Journal:  Korean J Physiol Pharmacol       Date:  2008-10-31       Impact factor: 2.016

7.  [Intrathecal and epidural administration of non-opioid analgesics in acute and chronic pain treatment.].

Authors:  B Donner; M Tryba; M Zenz; M Strumpf
Journal:  Schmerz       Date:  1994-06       Impact factor: 1.107

8.  Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach.

Authors:  Toshiharu Yasaka; Sheena Y X Tiong; David I Hughes; John S Riddell; Andrew J Todd
Journal:  Pain       Date:  2010-11       Impact factor: 7.926

9.  A quantitative study of inhibitory interneurons in laminae I-III of the mouse spinal dorsal horn.

Authors:  Erika Polgár; Camille Durrieux; David I Hughes; Andrew J Todd
Journal:  PLoS One       Date:  2013-10-25       Impact factor: 3.240

10.  Somatostatin and its 2A receptor in dorsal root ganglia and dorsal horn of mouse and human: expression, trafficking and possible role in pain.

Authors:  Tie-Jun Sten Shi; Qiong Xiang; Ming-Dong Zhang; Swapnali Barde; Ylva Kai-Larsen; Kaj Fried; Anna Josephson; Laura Glück; Sergey M Deyev; Andrei V Zvyagin; Stefan Schulz; Tomas Hökfelt
Journal:  Mol Pain       Date:  2014-02-13       Impact factor: 3.395
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.