What is the Meaning of Anaphase-Promoting Complex 7 in Malignant Neoplasms?

See Article on Page 139-145

When malignant neoplasms are compared to normal cells or benign neoplasms, malignant neoplasms are found to have several characteristics: more rapid increase in size, anaplasia, invasion, and metastasis. Cytologic features of malignant neoplasm cells include increased nuclear size, pleomorphism, anaplasia, hyperchromatism, and bizarre mitoses. Two main theories are used to explain these characteristics of malignant neoplasms: gene-mutation hypothesis and aneuploidy hypothesis.

Hanahan and Weinberg [1] have proposed 6 hallmarks of cancer that include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. These hallmarks can explain well the gene-mutation hypothesis related to multistep tumorigenesis [2]. Molecular biologist Duesberg [3], who identified oncogene v-src, at first rejected the genemutation hypothesis. He supported the aneuploidy hypothesis, first proposed in 1914 by Theodor Heinrich Boveri, that cancer results from chromosome disruption rather than from a few gene mutations [4].

In this issue, Kim et al. [5] examined the relationship between anaphase-promoting complex (APC) expression and clinicopathological factors based on immunohistochemical staining. The authors' main conclusion was that the loss of APC expression in colorectal tumor tissues may be related with the risk for recurrence and poorer survival rate. The background of this study was the roles played by APC in mitotic cell-cycle progression. The inactivation of APC is thought to be a cause of abnormal chromosome segregation that results in aneuploidy [67]. Recently, many studies have discussed the relationship between chromosomal instability (CIN) and aneuploidy. Some studies have reported that CIN induces aneuploidy while others have reported that aneuploidy is not the result of malignant changes, but the cause of malignant changes [189]. Inactivation of the APC gene mediates chromosomal segregation and aneuploidy, so I think the importance of the APC gene is the point. A better understanding of the mechanism controlling the function of the APC gene will eventually lead to new strategies to combat cancer [101112].