Brenda C T Kieboom1, Silvan Licher1, Frank J Wolters1, M Kamran Ikram1, Ewout J Hoorn1, Robert Zietse1, Bruno H Stricker2, M Arfan Ikram1. 1. From the Departments of Epidemiology (B.C.T.K., S.L., F.J.W., M.K.I., B.H.S., M.A.I.), Internal Medicine (B.C.T.K., E.J.H., R.Z., B.H.S.), and Neurology (S.L., F.J.W., M.K.I.), Erasmus MC-University Medical Center Rotterdam; and Inspectorate of Health Care (B.C.T.K., B.H.S.), Utrecht, the Netherlands. 2. From the Departments of Epidemiology (B.C.T.K., S.L., F.J.W., M.K.I., B.H.S., M.A.I.), Internal Medicine (B.C.T.K., E.J.H., R.Z., B.H.S.), and Neurology (S.L., F.J.W., M.K.I.), Erasmus MC-University Medical Center Rotterdam; and Inspectorate of Health Care (B.C.T.K., B.H.S.), Utrecht, the Netherlands. b.stricker@erasmusmc.nl.
Abstract
OBJECTIVE: To determine if serum magnesium levels are associated with the risk of all-cause dementia and Alzheimer disease. METHODS: Within the prospective population-based Rotterdam Study, we measured serum magnesium levels in 9,569 participants, free from dementia at baseline (1997-2008). Participants were subsequently followed up for incident dementia, determined according to the DSM-III-R criteria, until January 1, 2015. We used Cox proportional hazard regression models to associate quintiles of serum magnesium with incident all-cause dementia. We used the third quintile as a reference group and adjusted for age, sex, Rotterdam Study cohort, educational level, cardiovascular risk factors, kidney function, comorbidities, other electrolytes, and diuretic use. RESULTS: Our study population had a mean age of 64.9 years and 56.6% were women. During a median follow-up of 7.8 years, 823 participants were diagnosed with all-cause dementia. Both low serum magnesium levels (≤0.79 mmol/L) and high serum magnesium levels (≥0.90 mmol/L) were associated with an increased risk of dementia (hazard ratio [HR] 1.32, 95% confidence interval [CI] 1.02-1.69, and HR 1.30, 95% CI 1.02-1.67, respectively). CONCLUSIONS: Both low and high serum magnesium levels are associated with an increased risk of all-cause dementia. Our results warrant replication in other population-based studies.
OBJECTIVE: To determine if serum magnesium levels are associated with the risk of all-cause dementia and Alzheimer disease. METHODS: Within the prospective population-based Rotterdam Study, we measured serum magnesium levels in 9,569 participants, free from dementia at baseline (1997-2008). Participants were subsequently followed up for incident dementia, determined according to the DSM-III-R criteria, until January 1, 2015. We used Cox proportional hazard regression models to associate quintiles of serum magnesium with incident all-cause dementia. We used the third quintile as a reference group and adjusted for age, sex, Rotterdam Study cohort, educational level, cardiovascular risk factors, kidney function, comorbidities, other electrolytes, and diuretic use. RESULTS: Our study population had a mean age of 64.9 years and 56.6% were women. During a median follow-up of 7.8 years, 823 participants were diagnosed with all-cause dementia. Both low serum magnesium levels (≤0.79 mmol/L) and high serum magnesium levels (≥0.90 mmol/L) were associated with an increased risk of dementia (hazard ratio [HR] 1.32, 95% confidence interval [CI] 1.02-1.69, and HR 1.30, 95% CI 1.02-1.67, respectively). CONCLUSIONS: Both low and high serum magnesium levels are associated with an increased risk of all-cause dementia. Our results warrant replication in other population-based studies.
Authors: Jeroen H F de Baaij; Detlef Bockenhauer; Felix Claverie-Martin; Joost G J Hoenderop; Ewout J Hoorn; Pascal Houillier; Nine V A M Knoers; Martin Konrad; Dominik Müller; Tom Nijenhuis; Karl Peter Schlingmann; Rosa Vargas Poussou Journal: Eur J Nutr Date: 2022-09-27 Impact factor: 4.865
Authors: Cheng Chen; Pengcheng Xun; Frederick Unverzagt; Leslie A McClure; Marguerite Ryan Irvin; Suzanne Judd; Mary Cushman; Ka He Journal: Eur J Nutr Date: 2020-07-31 Impact factor: 5.614