Literature DB >> 2893140

Genomic imprinting and carcinogenesis.

R J Wilkins1.   

Abstract

Genomic imprinting might play an important part in the development of several tumours. It is suggested that in Wilms' tumorigenesis, imprinting normally renders inactive a transforming gene on the maternally derived chromosome 11, leaving intact the paternally inherited chromosome 11 and the Wilms' transforming gene that it carries. A similar mechanism might account for the inheritance patterns of other tumours.

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Mesh：

Year:  1988        PMID： 2893140     DOI： 10.1016/s0140-6736(88)91121-x

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  14 in total

1.  The aetiology of cancer in the very young.

Authors:  J D Buckley
Journal:  Br J Cancer Suppl       Date:  1992-08

Review 2.  Genomic imprinting: review and relevance to human diseases.

Authors:  J G Hall
Journal:  Am J Hum Genet       Date:  1990-05       Impact factor: 11.025

Review 3.  Review and hypotheses: somatic mosaicism: observations related to clinical genetics.

Authors:  J G Hall
Journal:  Am J Hum Genet       Date:  1988-10       Impact factor: 11.025

4.  Genomic imprinting and the Beckwith-Wiedemann syndrome.

Authors:  K W Brown; J C Williams; N J Maitland; M G Mott
Journal:  Am J Hum Genet       Date:  1990-05       Impact factor: 11.025

Review 5.  Genomic imprinting: mechanism and role in human pathology.

Authors:  B Tycko
Journal:  Am J Pathol       Date:  1994-03       Impact factor: 4.307

Review 6.  Genetic imprinting in the mouse: implications for gene regulation.

Authors:  B M Cattanach; J Jones
Journal:  J Inherit Metab Dis       Date:  1994       Impact factor: 4.982

7.  Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5.

Authors:  A Koufos; P Grundy; K Morgan; K A Aleck; T Hadro; B C Lampkin; A Kalbakji; W K Cavenee
Journal:  Am J Hum Genet       Date:  1989-05       Impact factor: 11.025

8.  Excess of multifocal tumors in nephroblastoma: implications for mechanisms of tumor development and genetic counseling.

Authors:  C Bonaïti-Pellié; A Chompret; M F Tournade; J Lemerle; P A Voute; J F Delemarre
Journal:  Hum Genet       Date:  1993-05       Impact factor: 4.132

9.  Occasional loss of constitutive heterozygosity at 11p15.5 and imprinting relaxation of the IGFII maternal allele in hepatoblastoma.

Authors:  M Montagna; C Menin; L Chieco-Bianchi; E D'Andrea
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

10.  A model for embryonal rhabdomyosarcoma tumorigenesis that involves genome imprinting.

Authors:  H Scrable; W Cavenee; F Ghavimi; M Lovell; K Morgan; C Sapienza
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205
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