Literature DB >> 28930654

A Tale of Two Genes: Microglial Apoe and Trem2.

Anna A Pimenova1, Edoardo Marcora2, Alison M Goate3.   

Abstract

Microglial cell function is implicated in the etiology of Alzheimer's disease by human genetics. In this issue of Immunity, Krasemann et al. (2017) describe a gene expression signature associated with an APOE- and TREM2-dependent response of microglia to brain tissue damage that accumulates in aging and disease, defining an axis that might be amenable to therapeutic targeting.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28930654     DOI： 10.1016/j.immuni.2017.08.015

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  21 in total

Review 1.  Advances in Genetic and Molecular Understanding of Alzheimer's Disease.

Authors:  Laura Ibanez; Carlos Cruchaga; Maria Victoria Fernández
Journal:  Genes (Basel)       Date:  2021-08-15       Impact factor: 4.096

2.  Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia.

Authors:  Na Zhao; Wenhui Qiao; Fuyao Li; Yingxue Ren; Jiaying Zheng; Yuka A Martens; Xusheng Wang; Ling Li; Chia-Chen Liu; Kai Chen; Yiyang Zhu; Tadafumi C Ikezu; Zonghua Li; Axel D Meneses; Yunjung Jin; Joshua A Knight; Yixing Chen; Ligia Bastea; Cynthia Linares; Berkiye Sonustun; Lucy Job; Madeleine L Smith; Manling Xie; Yong U Liu; Anthony D Umpierre; Koichiro Haruwaka; Zachary S Quicksall; Peter Storz; Yan W Asmann; Long-Jun Wu; Guojun Bu
Journal:  J Exp Med       Date:  2022-09-15       Impact factor: 17.579

Review 3.  Microglia: Friend and foe in tauopathy.

Authors:  Kristian F Odfalk; Kevin F Bieniek; Sarah C Hopp
Journal:  Prog Neurobiol       Date:  2022-06-14       Impact factor: 10.885

Review 4.  The Neuro-Immune-Regulators (NIREGs) Promote Tissue Resilience; a Vital Component of the Host's Defense Strategy against Neuroinflammation.

Authors:  Yosra Bedoui; Jim W Neal; Philippe Gasque
Journal:  J Neuroimmune Pharmacol       Date:  2018-06-16       Impact factor: 4.147

5.  Longitudinal monitoring of microglial/macrophage activation in ischemic rat brain using Iba-1-specific nanoparticle-enhanced magnetic resonance imaging.

Authors:  Laurel O Sillerud; Yirong Yang; Lisa Y Yang; Kelsey B Duval; Jeffrey Thompson; Yi Yang
Journal:  J Cereb Blood Flow Metab       Date:  2020-09-22       Impact factor: 6.200

6.  Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.

Authors:  Sarah K Baker; Zu-Lin Chen; Erin H Norris; Alexey S Revenko; A Robert MacLeod; Sidney Strickland
Journal:  Proc Natl Acad Sci U S A       Date:  2018-09-25       Impact factor: 11.205

7.  Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response.

Authors:  Anna A Pimenova; Manon Herbinet; Ishaan Gupta; Saima I Machlovi; Kathryn R Bowles; Edoardo Marcora; Alison M Goate
Journal:  Neurobiol Dis       Date:  2020-12-08       Impact factor: 5.996

Review 8.  Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies.

Authors:  Yu Yamazaki; Na Zhao; Thomas R Caulfield; Chia-Chen Liu; Guojun Bu
Journal:  Nat Rev Neurol       Date:  2019-07-31       Impact factor: 44.711

Review 9.  Targeting microglia L-type voltage-dependent calcium channels for the treatment of central nervous system disorders.

Authors:  Sarah C Hopp
Journal:  J Neurosci Res       Date:  2020-01-29       Impact factor: 4.433

Review 10.  TREM2 ectodomain and its soluble form in Alzheimer's disease.

Authors:  Jiaolong Yang; Zhihui Fu; Xingyu Zhang; Min Xiong; Lanxia Meng; Zhentao Zhang
Journal:  J Neuroinflammation       Date:  2020-07-07       Impact factor: 8.322
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