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Literature DB >> 28930597

The store-operated calcium channels in cancer metastasis: from cell migration, invasion to metastatic colonization.

Abstract

Store-operated calcium entry (SOCE) is the predominant calcium entry mechanism in most cancer cells. SOCE is mediated by the endoplasmic reticulum calcium sensor STIMs (STIM1 and 2) and plasma membrane channel forming unit Orais (Orai 1-3). In recent years there is increasing evidence indicating that SOCE in cancer cells is dysregulated to promote cancer cell migration, invasion and metastasis. The overexpression of STIM and Orai proteins has been reported to correlate with the metastatic progression of various cancers. The hyperactive SOCE may promote metastatic dissemination and colonization by reorganizing the actin cytoskeleton, degrading the extracellular matrix and remodeling the tumor microenvironment. Here we discuss how these recent progresses provide novel insights to our understanding of tumor metastasis.

Entities: Chemical

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Year: 2018 PMID： 28930597 PMCID： PMC5632947 DOI： 10.2741/4641

Source DB: PubMed Journal: Front Biosci (Landmark Ed) ISSN： 2768-6698

130 in total

1. Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses.

Authors: Yoshihiro Baba; Keigo Nishida; Yoko Fujii; Toshio Hirano; Masaki Hikida; Tomohiro Kurosaki
Journal: Nat Immunol Date: 2007-12-02 Impact factor: 25.606

Review 2. STIM and Orai: dynamic intermembrane coupling to control cellular calcium signals.

Authors: Xiaoxiang Deng; Youjun Wang; Yandong Zhou; Jonathan Soboloff; Donald L Gill
Journal: J Biol Chem Date: 2009-05-27 Impact factor: 5.157

Review 3. Life at the leading edge.

Authors: Anne J Ridley
Journal: Cell Date: 2011-06-24 Impact factor: 41.582

4. Orai3 is an estrogen receptor α-regulated Ca²⁺ channel that promotes tumorigenesis.

Authors: Rajender K Motiani; Xuexin Zhang; Kelly E Harmon; Rebecca S Keller; Khalid Matrougui; James A Bennett; Mohamed Trebak
Journal: FASEB J Date: 2012-09-19 Impact factor: 5.191

5. The Orai1 Store-operated Calcium Channel Functions as a Hexamer.

Authors: Xiangyu Cai; Yandong Zhou; Robert M Nwokonko; Natalia A Loktionova; Xianming Wang; Ping Xin; Mohamed Trebak; Youjun Wang; Donald L Gill
Journal: J Biol Chem Date: 2016-10-25 Impact factor: 5.157

6. Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis.

Authors: Erik Sahai; Christopher J Marshall
Journal: Nat Cell Biol Date: 2003-08 Impact factor: 28.824

7. Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation.

Authors: Rajesh Kumar Gandhirajan; Shu Meng; Harish C Chandramoorthy; Karthik Mallilankaraman; Salvatore Mancarella; Hui Gao; Roshanak Razmpour; Xiao-Feng Yang; Steven R Houser; Ju Chen; Walter J Koch; Hong Wang; Jonathan Soboloff; Donald L Gill; Muniswamy Madesh
Journal: J Clin Invest Date: 2013-01-25 Impact factor: 14.808

Review 8. CRAC channels, calcium, and cancer in light of the driver and passenger concept.

Authors: Markus Hoth
Journal: Biochim Biophys Acta Date: 2015-12-17

9. STIM1, an essential and conserved component of store-operated Ca2+ channel function.

Authors: Jack Roos; Paul J DiGregorio; Andriy V Yeromin; Kari Ohlsen; Maria Lioudyno; Shenyuan Zhang; Olga Safrina; J Ashot Kozak; Steven L Wagner; Michael D Cahalan; Gönül Veliçelebi; Kenneth A Stauderman
Journal: J Cell Biol Date: 2005-05-02 Impact factor: 10.539

10. Elevated Orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma.

Authors: Hua Zhu; Hui Zhang; Feng Jin; Mingzhu Fang; Mark Huang; Chung S Yang; Tong Chen; Liwu Fu; Zui Pan
Journal: Oncotarget Date: 2014-06-15

26 in total

1. Transcriptional and epigenetic landscape of Ca²⁺-signaling genes in hepatocellular carcinoma.

Authors: Andrés Hernández-Oliveras; Eduardo Izquierdo-Torres; Guadalupe Hernández-Martínez; Ángel Zarain-Herzberg; Juan Santiago-García
Journal: J Cell Commun Signal Date: 2021-01-04 Impact factor: 5.782

Review 2. Ca²⁺ as a therapeutic target in cancer.

Authors: Scott Gross; Pranava Mallu; Hinal Joshi; Bryant Schultz; Christina Go; Jonathan Soboloff
Journal: Adv Cancer Res Date: 2020-07-09 Impact factor: 6.242

Review 3. Mitochondrial Involvement in Migration, Invasion and Metastasis.

Authors: Tatiana V Denisenko; Anna S Gorbunova; Boris Zhivotovsky
Journal: Front Cell Dev Biol Date: 2019-12-20

4. Imaging elemental events of store-operated Ca²⁺ entry in invading cancer cells with plasmalemmal targeted sensors.

Authors: Fujian Lu; Jianwei Sun; Qiaoxia Zheng; Jinghang Li; Yuanzhao Hu; Peng Yu; Huifang He; Yan Zhao; Xianhua Wang; Shengyu Yang; Heping Cheng
Journal: J Cell Sci Date: 2019-03-25 Impact factor: 5.285

Review 5. Spatiotemporal regulation of store-operated calcium entry in cancer metastasis.

Authors: Fujian Lu; Yunzhan Li; Shengchen Lin; Heping Cheng; Shengyu Yang
Journal: Biochem Soc Trans Date: 2021-12-17 Impact factor: 4.919

6. Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer.

Authors: Xiuchao Wang; Yunzhan Li; Zekun Li; Shengchen Lin; Hongwei Wang; Jianwei Sun; Chungen Lan; Liangliang Wu; Dongxiao Sun; Chongbiao Huang; Pankaj K Singh; Nadine Hempel; Mohamed Trebak; Gina M DeNicola; Jihui Hao; Shengyu Yang
Journal: Cancer Res Date: 2022-06-15 Impact factor: 13.312

7. Suppression of store-operated Ca²⁺ entry regulated by silencing Orai1 inhibits C6 glioma cell motility via decreasing Pyk2 activity and promoting focal adhesion.

Authors: Meng Zhu; Bingke Lv; Wenjing Ge; Zhenwen Cui; Kai Zhao; Yugong Feng; Xuejun Yang
Journal: Cell Cycle Date: 2020-12-03 Impact factor: 4.534

The store-operated calcium channels in cancer metastasis: from cell migration, invasion to metastatic colonization.

1. Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses.

Review 2. STIM and Orai: dynamic intermembrane coupling to control cellular calcium signals.

Review 3. Life at the leading edge.

4. Orai3 is an estrogen receptor α-regulated Ca²⁺ channel that promotes tumorigenesis.

5. The Orai1 Store-operated Calcium Channel Functions as a Hexamer.

6. Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis.

7. Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation.

Review 8. CRAC channels, calcium, and cancer in light of the driver and passenger concept.

9. STIM1, an essential and conserved component of store-operated Ca2+ channel function.

10. Elevated Orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma.

1. Transcriptional and epigenetic landscape of Ca²⁺-signaling genes in hepatocellular carcinoma.

Review 2. Ca²⁺ as a therapeutic target in cancer.

Review 3. Mitochondrial Involvement in Migration, Invasion and Metastasis.

4. Imaging elemental events of store-operated Ca²⁺ entry in invading cancer cells with plasmalemmal targeted sensors.

Review 5. Spatiotemporal regulation of store-operated calcium entry in cancer metastasis.

6. Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer.

7. Suppression of store-operated Ca²⁺ entry regulated by silencing Orai1 inhibits C6 glioma cell motility via decreasing Pyk2 activity and promoting focal adhesion.

8. Role of endolysosomes and pH in the pathogenesis and treatment of glioblastoma.

Review 9. Store Operated Calcium Entry in Cell Migration and Cancer Metastasis.

10. TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer.

Review 2. STIM and Orai: dynamic intermembrane coupling to control cellular calcium signals.

Review 3. Life at the leading edge.

Review 8. CRAC channels, calcium, and cancer in light of the driver and passenger concept.

Review 2. Ca2+ as a therapeutic target in cancer.

Review 3. Mitochondrial Involvement in Migration, Invasion and Metastasis.

Review 5. Spatiotemporal regulation of store-operated calcium entry in cancer metastasis.

Review 9. Store Operated Calcium Entry in Cell Migration and Cancer Metastasis.

Review 2. Ca²⁺ as a therapeutic target in cancer.