Literature DB >> 28930583

Ibuprofen as a template molecule for drug design against Ebola virus.

Slobodan Paessler1, Cheng Huang1, Milan Sencanski2, Nevena Veljkovic2, Vladimir Perovic2, Sanja Glisic2, Veljjko Veljkovic3.   

Abstract

The Ebola virus outbreak in West Africa 2015 and Congo 2017, point out an urgent need for development of drugs against this important pathogen. Previously, by repurposing virtual screening of 6438 drugs from DrugBank, ibuprofen was selected as a possible inhibitor of the Ebola virus infection. The results of an additional docking analysis as well as experimental results showing measurable anti-Ebola effect of ibuprofen in cell culture suggest ibuprofen as a promising molecular template for the development of drugs for treatment of the infection by Ebola virus.

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Year:  2018        PMID： 28930583     DOI： 10.2741/4627

Source DB:  PubMed          Journal:  Front Biosci (Landmark Ed)        ISSN： 2768-6698


  11 in total

1.  Virtual Screen for Repurposing of Drugs for Candidate Influenza a M2 Ion-Channel Inhibitors.

Authors:  Draginja Radosevic; Milan Sencanski; Vladimir Perovic; Nevena Veljkovic; Jelena Prljic; Veljko Veljkovic; Emily Mantlo; Natalya Bukreyeva; Slobodan Paessler; Sanja Glisic
Journal:  Front Cell Infect Microbiol       Date:  2019-03-26       Impact factor: 5.293

Review 2.  Decoding the enigma of antiviral crisis: Does one target molecule regulate all?

Authors:  Abdullah Mahmud-Al-Rafat; Apurba Majumder; K M Taufiqur Rahman; A M Mahedi Hasan; K M Didarul Islam; Andrew W Taylor-Robinson; Md Morsaline Billah
Journal:  Cytokine       Date:  2019-01-04       Impact factor: 3.861

Review 3.  Repurposing approved drugs on the pathway to novel therapies.

Authors:  Catherine H Schein
Journal:  Med Res Rev       Date:  2019-08-20       Impact factor: 12.944

4.  Luminore CopperTouch™ surface coating effectively inactivates SARS-CoV-2, Ebola and Marburg viruses in vitro.

Authors:  Emily K Mantlo; Slobodan Paessler; Alexey Seregin; Alfred Mitchell
Journal:  medRxiv       Date:  2020-07-14

5.  Ibuprofen, a traditional drug that may impact the course of COVID-19 new effective formulation in nebulizable solution.

Authors:  Néstor H García; Daniela J Porta; Roxana V Alasino; Sonia E Muñoz; Dante M Beltramo
Journal:  Med Hypotheses       Date:  2020-07-07       Impact factor: 1.538

Review 6.  Advances in Designing and Developing Vaccines, Drugs, and Therapies to Counter Ebola Virus.

Authors:  Kuldeep Dhama; Kumaragurubaran Karthik; Rekha Khandia; Sandip Chakraborty; Ashok Munjal; Shyma K Latheef; Deepak Kumar; Muthannan Andavar Ramakrishnan; Yashpal Singh Malik; Rajendra Singh; Satya Veer Singh Malik; Raj Kumar Singh; Wanpen Chaicumpa
Journal:  Front Immunol       Date:  2018-08-10       Impact factor: 7.561

7.  Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.

Authors:  Veljko Veljkovic; Júlia Vergara-Alert; Joaquim Segalés; Slobodan Paessler
Journal:  F1000Res       Date:  2020-01-27

8.  Antiviral Agents Against Ebola Virus Infection: Repositioning Old Drugs and Finding Novel Small Molecules.

Authors:  Elisa Fanunza; Aldo Frau; Angela Corona; Enzo Tramontano
Journal:  Annu Rep Med Chem       Date:  2018-09-22       Impact factor: 1.059

9.  Molecular docking enabled updated screening of the matrix protein VP40 from Ebola virus with millions of compounds in the MCULE database for potential inhibitors.

Authors:  Hasanain Abdulhameed Odhar; Ali Mahmood Rayshan; Salam Waheed Ahjel; Alaa Abduljabbar Hashim; Ali A Mohammed Ali Albeer
Journal:  Bioinformation       Date:  2019-10-08

10.  Identification of SARS-CoV-2 Papain-like Protease (PLpro) Inhibitors Using Combined Computational Approach.

Authors:  Milan Sencanski; Vladimir Perovic; Jelena Milicevic; Tamara Todorovic; Radivoje Prodanovic; Veljko Veljkovic; Slobodan Paessler; Sanja Glisic
Journal:  ChemistryOpen       Date:  2022-02       Impact factor: 2.630
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