Denis Vinnikov1,2, Sergey Semizhon3, Tatsyana Rybina4, Ludmila Savich3, Vicktor Scherbitsky5, Igor Manichev5. 1. al-Farabi Kazakh National University, Almaty, Kazakhstan. 2. Biological institute, National Research Tomsk State University, Tomsk, Russian Federation. 3. Minsk Tractor Plant, Minsk, Republic of Belarus. 4. National Center of Occupational Safety and Health, Minsk, Republic of Belarus. 5. Belintelmed, Minsk, Republic of Belarus.
Abstract
BACKGROUND: The aim of this study was to measure the association of exposure to dust at workplace with COPD using objective methods of exposure and outcome classification. METHODS: Forced expiratory volume in one second (FEV1 ) to forced vital capacity (FVC) <70%; FVC below LLN, and FEV1 below LLN from the annual screening of Minsk Tractor Plant workers (N = 458) were tested for predictors in an adjusted logistic regression model. RESULTS: In a regression model, adjusted for pack-years of smoking, age, sex, and work duration, work in highly exposed workplaces was associated with FEV1 /FVC<70% (odds ratio (OR) 2.10 (95% confidence interval (CI) 1.16;3.83); and FEV1 <LLN (OR 2.24 (95% CI 1.18;4.25)). Given the fraction of workers exposed 0.20, population attributable fraction (PAF%) of COPD due to dust exposure was 18%. CONCLUSIONS: Workers in highly exposed to dust workplaces had double odds of developing COPD.
BACKGROUND: The aim of this study was to measure the association of exposure to dust at workplace with COPD using objective methods of exposure and outcome classification. METHODS: Forced expiratory volume in one second (FEV1 ) to forced vital capacity (FVC) <70%; FVC below LLN, and FEV1 below LLN from the annual screening of Minsk Tractor Plant workers (N = 458) were tested for predictors in an adjusted logistic regression model. RESULTS: In a regression model, adjusted for pack-years of smoking, age, sex, and work duration, work in highly exposed workplaces was associated with FEV1 /FVC<70% (odds ratio (OR) 2.10 (95% confidence interval (CI) 1.16;3.83); and FEV1 <LLN (OR 2.24 (95% CI 1.18;4.25)). Given the fraction of workers exposed 0.20, population attributable fraction (PAF%) of COPD due to dust exposure was 18%. CONCLUSIONS: Workers in highly exposed to dust workplaces had double odds of developing COPD.