Literature DB >> 28930310

Lipid radicals cause light-induced retinal degeneration.

Masataka Enoki1, Saki Shinto, Yuta Matsuoka, Ayasa Otsuka, Sachiko Kaidzu, Masaki Tanito, Takahiro Shibata, Koji Uchida, Akihiro Ohira, Mayumi Yamato, Ken-Ichi Yamada.   

Abstract

Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.

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Year:  2017        PMID: 28930310     DOI: 10.1039/c7cc03387g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  2 in total

1.  Radioiodinated Nitroxide Derivative for the Detection of Lipid Radicals.

Authors:  Toshihide Yamasaki; Risa Azuma; Kohei Sano; Masayuki Munekane; Yuta Matsuoka; Ken-Ichi Yamada; Takahiro Mukai
Journal:  ACS Med Chem Lett       Date:  2019-12-03       Impact factor: 4.345

2.  Progranulin protects the mouse retina under hypoxic conditions via inhibition of the Toll‑like receptor‑4‑NADPH oxidase 4 signaling pathway.

Authors:  Zhi-Peng You; Meng-Jia Yu; Yu-Lan Zhang; Ke Shi
Journal:  Mol Med Rep       Date:  2018-11-08       Impact factor: 2.952

  2 in total

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