Silas Culver1, Caixia Li1, Helmy M Siragy2. 1. Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, P.O. Box 801409, Charlottesville, VA, 22908-1409, USA. 2. Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, P.O. Box 801409, Charlottesville, VA, 22908-1409, USA. hms7a@virginia.edu.
Abstract
PURPOSE OF REVIEW: The intrarenal renin-angiotensin-aldosterone system (RAS) is an independent paracrine hormonal system with an increasingly prominent role in hypertension and renal disease. Two enzyme components of this system are angiotensin-converting enzyme (ACE) and more recently discovered ACE2. The purpose of this review is to describe recent discoveries regarding the roles of intrarenal ACE and ACE2 and their interaction. RECENT FINDINGS: Renal tubular ACE contributes to salt-sensitive hypertension. Additionally, the relative expression and activity of intrarenal ACE and ACE2 are central to promoting or inhibiting different renal pathologies including renovascular hypertension, diabetic nephropathy, and renal fibrosis. Renal ACE and ACE2 represent two opposing axes within the intrarenal RAS system whose interaction determines the progression of several common disease processes. While this relationship remains complex and incompletely understood, further investigations hold the potential for creating novel approaches to treating hypertension and kidney disease.
PURPOSE OF REVIEW: The intrarenal renin-angiotensin-aldosterone system (RAS) is an independent paracrine hormonal system with an increasingly prominent role in hypertension and renal disease. Two enzyme components of this system are angiotensin-converting enzyme (ACE) and more recently discovered ACE2. The purpose of this review is to describe recent discoveries regarding the roles of intrarenal ACE and ACE2 and their interaction. RECENT FINDINGS:Renal tubularACE contributes to salt-sensitive hypertension. Additionally, the relative expression and activity of intrarenal ACE and ACE2 are central to promoting or inhibiting different renal pathologies including renovascular hypertension, diabetic nephropathy, and renal fibrosis. Renal ACE and ACE2 represent two opposing axes within the intrarenal RAS system whose interaction determines the progression of several common disease processes. While this relationship remains complex and incompletely understood, further investigations hold the potential for creating novel approaches to treating hypertension and kidney disease.
Authors: Minghao Ye; Jan Wysocki; Josette William; Maria José Soler; Ivan Cokic; Daniel Batlle Journal: J Am Soc Nephrol Date: 2006-10-04 Impact factor: 10.121
Authors: Eun Hui Bae; Fei Fang; Vanessa R Williams; Ana Konvalinka; Xiaohua Zhou; Vaibhav B Patel; Xuewen Song; Rohan John; Gavin Y Oudit; York Pei; James W Scholey Journal: Kidney Int Date: 2017-02-27 Impact factor: 10.612
Authors: Romer A Gonzalez-Villalobos; Ryousuke Satou; Naro Ohashi; Laura C Semprun-Prieto; Akemi Katsurada; Catherine Kim; G M Upchurch; Minolfa C Prieto; Hiroyuki Kobori; L Gabriel Navar Journal: Am J Physiol Renal Physiol Date: 2009-10-21
Authors: Christoph H Osterreicher; Kojiro Taura; Samuele De Minicis; Ekihiro Seki; Melitta Penz-Osterreicher; Yuzo Kodama; Johannes Kluwe; Manfred Schuster; Gavin Y Oudit; Josef M Penninger; David A Brenner Journal: Hepatology Date: 2009-09 Impact factor: 17.425
Authors: Sergi Clotet; María José Soler; Marta Rebull; Javier Gimeno; Susan B Gurley; Julio Pascual; Marta Riera Journal: J Hypertens Date: 2016-09 Impact factor: 4.844
Authors: Max C Liebau; D Lang; J Böhm; N Endlich; Martin J Bek; Ian Witherden; Peter W Mathieson; Moin A Saleem; Hermann Pavenstädt; Karl-Georg Fischer Journal: Am J Physiol Renal Physiol Date: 2005-09-27
Authors: Glaucia E Callera; Tayze T Antunes; Jose W Correa; Danielle Moorman; Alexey Gutsol; Ying He; Aurelie Nguyen Dinh Cat; Ana M Briones; Augusto C Montezano; Kevin D Burns; Rhian M Touyz Journal: Biosci Rep Date: 2016-10-27 Impact factor: 3.840
Authors: Jorge F Giani; Luciana C Veiras; Justin Z Y Shen; Ellen A Bernstein; DuoYao Cao; Derick Okwan-Duodu; Zakir Khan; Romer A Gonzalez-Villalobos; Kenneth E Bernstein Journal: Mol Cell Endocrinol Date: 2021-03-26 Impact factor: 4.369