| Literature DB >> 2892919 |
O Al-Sayed-Omar1, A Johnston, P Turner.
Abstract
Buccal absorption of morphine sulphate and morphine-3-glucuronide at various buffer pH values (4 to 10) over 5 min has been investigated in seven and four normal healthy volunteers, respectively. Increasing pH caused an increase in buccal absorption of both. The maximum mean absorption was 37% at pH 10 for morphine and 19% at pH 8 for morphine-3-glucuronide.Entities:
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Year: 1987 PMID： 2892919 DOI： 10.1111/j.2042-7158.1987.tb03132.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765