Surbhi Agrawal1, Christopher Jackson2, Karel-Bart Celie3, Chetan Dodhia4, Daphne Monie5, Jose Monzon6, Theodor Kaufman7, Nicholas J Hellenthal8. 1. Department of Surgery, Bassett Healthcare Network, Cooperstown, NY, USA. Electronic address: surbhi.agrawal@bassett.org. 2. Department of Surgery, Bassett Healthcare Network, Cooperstown, NY, USA. Electronic address: christopher.jackson@bassett.org. 3. Department of Surgery, Bassett Healthcare Network, Cooperstown, NY, USA. Electronic address: karel-bart.celie@bassett.org. 4. Department of Surgery, Bassett Healthcare Network, Cooperstown, NY, USA. 5. Department of Surgery, Bassett Healthcare Network, Cooperstown, NY, USA. Electronic address: daphne.monie@bassett.org. 6. Department of Surgery, Bassett Healthcare Network, Cooperstown, NY, USA. Electronic address: jose.monzon@bassett.org. 7. Department of Surgery, Bassett Healthcare Network, Cooperstown, NY, USA. Electronic address: theodor.kaufman@bassett.org. 8. Department of Surgery, Bassett Healthcare Network, Cooperstown, NY, USA. Electronic address: nicholas.hellenthal@bassett.org.
Abstract
PURPOSE: The prognosis for primary tracheal cancer is dismal. We investigated whether there has been improvement in survival in tracheal cancer patients and how treatment modality affected overall and cancer-specific survival. MATERIALS AND METHODS: Using the Surveillance, Epidemiology, and End Results database, 1144 patients with tracheal cancer were identified between 1973 and 2011. Patients were stratified by age group, gender, race, tumor histology, and treatment modality. Radical surgery and survival rates based upon these stratifications were determined. Longitudinal analyses of survival and the percentage of patients undergoing surgery and radiation were conducted. RESULTS: In the final cohort, 327 tracheal cancer patients (34%) underwent radical surgery. Patients of younger age, female gender, and who presented with non-squamous cell tumors were statistically more likely to undergo surgery. Over time, utilization of radiation has declined while use of radical surgery has increased. Concomitantly, 5-year survival has increased from approximately 25% in 1973 to 30% by 2006. Those who did not have surgery were 2.50 times more likely to die of tracheal cancer (95% Confidence Interval 2.00-3.11, p<0.001) than those who did have surgery. Additionally, patients who underwent radical surgery alone (without adjuvant radiation therapy) were 50% or 19% less likely to die of tracheal cancer than those who underwent no treatment or combination therapy, respectively (both p<0.001). CONCLUSIONS: Survival in patients with tracheal cancer is improving over time. The utilization of radical surgery is increasing and confers the highest survival advantage to patients who are candidates.
PURPOSE: The prognosis for primary tracheal cancer is dismal. We investigated whether there has been improvement in survival in tracheal cancerpatients and how treatment modality affected overall and cancer-specific survival. MATERIALS AND METHODS: Using the Surveillance, Epidemiology, and End Results database, 1144 patients with tracheal cancer were identified between 1973 and 2011. Patients were stratified by age group, gender, race, tumor histology, and treatment modality. Radical surgery and survival rates based upon these stratifications were determined. Longitudinal analyses of survival and the percentage of patients undergoing surgery and radiation were conducted. RESULTS: In the final cohort, 327 tracheal cancerpatients (34%) underwent radical surgery. Patients of younger age, female gender, and who presented with non-squamous cell tumors were statistically more likely to undergo surgery. Over time, utilization of radiation has declined while use of radical surgery has increased. Concomitantly, 5-year survival has increased from approximately 25% in 1973 to 30% by 2006. Those who did not have surgery were 2.50 times more likely to die of tracheal cancer (95% Confidence Interval 2.00-3.11, p<0.001) than those who did have surgery. Additionally, patients who underwent radical surgery alone (without adjuvant radiation therapy) were 50% or 19% less likely to die of tracheal cancer than those who underwent no treatment or combination therapy, respectively (both p<0.001). CONCLUSIONS: Survival in patients with tracheal cancer is improving over time. The utilization of radical surgery is increasing and confers the highest survival advantage to patients who are candidates.
Authors: Mohammad K Hararah; William A Stokes; Ayman Oweida; Tejas Patil; Arya Amini; Julie Goddard; Daniel W Bowles; Sana D Karam Journal: Laryngoscope Date: 2019-04-12 Impact factor: 3.325
Authors: Jiagen Li; Fengwei Tan; Yalong Wang; Qi Xue; Yushun Gao; Juwei Mu; Yousheng Mao; Jun Zhao; Dali Wang; Xiaoli Feng; Susheng Shi; Kenichi Suda; Giuseppe Cardillo; Luca Bertolaccini; Maurizio V Infante; Paul E Van Schil; Shugeng Gao; Jie He Journal: Transl Lung Cancer Res Date: 2022-05
Authors: HongXiang Gao; Xuan He; JianFei Du; SanHu Yang; Yang Wang; JunWei Zhang; ChenNian Zhao Journal: Cancer Manag Res Date: 2019-01-24 Impact factor: 3.989