Nicholas S Downing1, Jing Li2. 1. Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02116, USA. 2. National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing, 100037, People's Republic of China.