Ming-Xiong Huang1,2, Ashley Robb Swan1,2, Annemarie Angeles Quinto1,2, Scott Matthews3,4, Deborah L Harrington1,2, Sharon Nichols5, Barry J Bruder6, Corey C Snook7, Charles W Huang8, Dewleen G Baker1,9,10, Roland R Lee1,2. 1. a Radiology, Research, and Psychiatry Services, VA San Diego Healthcare System , San Diego , CA , USA. 2. b Department of Radiology , University of California San Diego , La Jolla , CA , USA. 3. c Department of Psychiatry , University of California San Diego , La Jolla , CA , USA. 4. d ASPIRE Center, VASDHS Residential Rehabilitation Treatment Program , San Diego , CA , USA. 5. e Department of Neurosciences , University of California San Diego , La Jolla , CA , USA. 6. f IASIS Technologies, Inc . Los Angeles , CA , USA. 7. g Mind-Brain Training Institute , Mount Dora , FL , USA. 8. h Department of Bioengineering , University of California San Diego , La Jolla , CA , USA. 9. i Department of Psychiatry, University of California San Diego , La Jolla , CA , USA. 10. j VA Center of Excellence for Stress and Mental Health , San Diego , CA , USA.
Abstract
BACKGROUND: Mild traumatic brain injury (mTBI) is a leading cause of sustained impairments in military service members, Veterans, and civilians. However, few treatments are available for mTBI, partially because the mechanism of persistent mTBI deficits is not fully understood. METHODS: We used magnetoencephalography (MEG) to investigate neuronal changes in individuals with mTBI following a passive neurofeedback-based treatment programme called IASIS. This programme involved applying low-intensity pulses using transcranial electrical stimulation (LIP-tES) with electroencephalography monitoring. Study participants included six individuals with mTBI and persistent post-concussive symptoms (PCS). MEG exams were performed at baseline and follow-up to evaluate the effect of IASIS on brain functioning. RESULTS: At the baseline MEG exam, all participants had abnormal slow-waves. In the follow-up MEG exam, the participants showed significantly reduced abnormal slow-waves with an average reduction of 53.6 ± 24.6% in slow-wave total score. The participants also showed significant reduction of PCS scores after IASIS treatment, with an average reduction of 52.76 ± 26.4% in PCS total score. CONCLUSIONS: The present study demonstrates, for the first time, the neuroimaging-based documentation of the effect of LIP-tES treatment on brain functioning in mTBI. The mechanisms of LIP-tES treatment are discussed, with an emphasis on LIP-tES's potentiation of the mTBI healing process.
BACKGROUND: Mild traumatic brain injury (mTBI) is a leading cause of sustained impairments in military service members, Veterans, and civilians. However, few treatments are available for mTBI, partially because the mechanism of persistent mTBI deficits is not fully understood. METHODS: We used magnetoencephalography (MEG) to investigate neuronal changes in individuals with mTBI following a passive neurofeedback-based treatment programme called IASIS. This programme involved applying low-intensity pulses using transcranial electrical stimulation (LIP-tES) with electroencephalography monitoring. Study participants included six individuals with mTBI and persistent post-concussive symptoms (PCS). MEG exams were performed at baseline and follow-up to evaluate the effect of IASIS on brain functioning. RESULTS: At the baseline MEG exam, all participants had abnormal slow-waves. In the follow-up MEG exam, the participants showed significantly reduced abnormal slow-waves with an average reduction of 53.6 ± 24.6% in slow-wave total score. The participants also showed significant reduction of PCS scores after IASIS treatment, with an average reduction of 52.76 ± 26.4% in PCS total score. CONCLUSIONS: The present study demonstrates, for the first time, the neuroimaging-based documentation of the effect of LIP-tES treatment on brain functioning in mTBI. The mechanisms of LIP-tES treatment are discussed, with an emphasis on LIP-tES's potentiation of the mTBI healing process.
Entities:
Keywords:
Flexyx neurotherapy system; low energy neurofeedback system; magnetoencephalography; slow-wave
Authors: Ming-Xiong Huang; Ashley Robb Swan; Annemarie Angeles Quinto; Jeffrey W Huang; Bianca G De-la-Garza; Charles W Huang; John R Hesselink; Erin D Bigler; Elisabeth A Wilde; Jeffrey E Max Journal: J Neurotrauma Date: 2019-12-31 Impact factor: 5.269
Authors: Deborah L Harrington; Po-Ya Hsu; Rebecca J Theilmann; Annemarie Angeles-Quinto; Ashley Robb-Swan; Sharon Nichols; Tao Song; Lu Le; Carl Rimmele; Scott Matthews; Kate A Yurgil; Angela Drake; Zhengwei Ji; Jian Guo; Chung-Kuan Cheng; Roland R Lee; Dewleen G Baker; Mingxiong Huang Journal: Diagnostics (Basel) Date: 2022-04-14
Authors: Molly Rea; Niall Holmes; Ryan M Hill; Elena Boto; James Leggett; Lucy J Edwards; David Woolger; Eliot Dawson; Vishal Shah; James Osborne; Richard Bowtell; Matthew J Brookes Journal: Neuroimage Date: 2021-07-15 Impact factor: 7.400