Literature DB >> 28925388

Structural step forward for NHEJ.

Go Watanabe1, Michael R Lieber1, Dewight Williams2.   

Abstract

In a recent paper published in Cell Research, a cryo-EM structure reveals the interface between DNA-PKcs and the Ku70/80:DNA complex, together forming the DNA-dependent protein kinase holoenzyme in non-homologous DNA end joining. Insight from this structure suggests how an allosteric rearrangement of DNA-PKcs driven by Ku70/80:DNA binding regulates kinase activity in this largest member of a family of structurally homologous phosphoinositide 3-kinase-related protein kinases that includes mTOR, ATR, and ATM.

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Year:  2017        PMID： 28925388      PMCID： PMC5674156          DOI： 10.1038/cr.2017.119

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  10 in total

1.  Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.

Authors:  J R Walker; R A Corpina; J Goldberg
Journal:  Nature       Date:  2001-08-09       Impact factor: 49.962

2.  Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair.

Authors:  Laura Spagnolo; Angel Rivera-Calzada; Laurence H Pearl; Oscar Llorca
Journal:  Mol Cell       Date:  2006-05-19       Impact factor: 17.970

3.  DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair.

Authors:  Bancinyane L Sibanda; Dimitri Y Chirgadze; David B Ascher; Tom L Blundell
Journal:  Science       Date:  2017-02-02       Impact factor: 47.728

4.  Cryo-EM structure of human DNA-PK holoenzyme.

Authors:  Xiaotong Yin; Mengjie Liu; Yuan Tian; Jiawei Wang; Yanhui Xu
Journal:  Cell Res       Date:  2017-08-25       Impact factor: 25.617

5.  Cryo-EM structure of the DNA-PK holoenzyme.

Authors:  Humayun Sharif; Yang Li; Yuanchen Dong; Liyi Dong; Wei Li Wang; Youdong Mao; Hao Wu
Journal:  Proc Natl Acad Sci U S A       Date:  2017-06-26       Impact factor: 11.205

Review 6.  Non-homologous DNA end joining and alternative pathways to double-strand break repair.

Authors:  Howard H Y Chang; Nicholas R Pannunzio; Noritaka Adachi; Michael R Lieber
Journal:  Nat Rev Mol Cell Biol       Date:  2017-05-17       Impact factor: 94.444

7.  Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding.

Authors:  Dewight R Williams; Kyung-Jong Lee; Jian Shi; David J Chen; Phoebe L Stewart
Journal:  Structure       Date:  2008-03       Impact factor: 5.006

Review 8.  Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining.

Authors:  Brandi L Mahaney; Katheryn Meek; Susan P Lees-Miller
Journal:  Biochem J       Date:  2009-02-01       Impact factor: 3.857

9.  Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini.

Authors:  R B West; M Yaneva; M R Lieber
Journal:  Mol Cell Biol       Date:  1998-10       Impact factor: 4.272

10.  The spatial organization of non-homologous end joining: from bridging to end joining.

Authors:  Takashi Ochi; Qian Wu; Tom L Blundell
Journal:  DNA Repair (Amst)       Date:  2014-03-11
  10 in total
  4 in total

Review 1.  Nonhomologous DNA end-joining for repair of DNA double-strand breaks.

Authors:  Nicholas R Pannunzio; Go Watanabe; Michael R Lieber
Journal:  J Biol Chem       Date:  2017-12-14       Impact factor: 5.157

2.  LINC-PINT impedes DNA repair and enhances radiotherapeutic response by targeting DNA-PKcs in nasopharyngeal cancer.

Authors:  You-Hong Wang; Zhen Guo; Liang An; Yong Zhou; Heng Xu; Jing Xiong; Zhao-Qian Liu; Xiao-Ping Chen; Hong-Hao Zhou; Xiong Li; Tao Liu; Wei-Hua Huang; Wei Zhang
Journal:  Cell Death Dis       Date:  2021-05-07       Impact factor: 8.469

Review 3.  p30 protein: a critical regulator of HTLV-1 viral latency and host immunity.

Authors:  Ramona Moles; Sarkis Sarkis; Veronica Galli; Maria Omsland; Damian F J Purcell; David Yurick; Georges Khoury; Cynthia A Pise-Masison; Genoveffa Franchini
Journal:  Retrovirology       Date:  2019-12-18       Impact factor: 4.602

4.  Positive Feedback Regulation of Poly(ADP-ribose) Polymerase 1 and the DNA-PK Catalytic Subunit Affects the Sensitivity of Nasopharyngeal Carcinoma to Etoposide.

Authors:  Lingyu Zhang; Yingting Zhuang; Guihui Tu; Ding Li; Yingjuan Fan; Shengnan Ye; Jianhua Xu; Ming Zheng; Ying Wu; Lixian Wu
Journal:  ACS Omega       Date:  2022-01-07
  4 in total

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