Florine Berger1, Selma Saâïd2, Teun van Gelder1,3, Bruno Stricker3,4, Matthijs Becker5, Patricia van den Bemt1. 1. Department of Hospital Pharmacy, Erasmus University Medical Centre, Rotterdam, the Netherlands. 2. Department of Hospital Pharmacy, Sint Franciscus Gasthuis, Rotterdam, the Netherlands. 3. Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, the Netherlands. 4. Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, the Netherlands. 5. Pharmacy Foundation of Haarlem Hospitals, Haarlem, the Netherlands.
Abstract
PURPOSE: In March 2013, regulatory warnings concerning the potential risks of domperidone caused considerable media attention in the Netherlands. The aim of the study was to assess the effect of regulatory warnings and the resulting media hype on the frequency of electrocardiogram (ECG) monitoring of inpatients using domperidone. We also studied the effect on the frequency of prescribing domperidone by physicians. METHODS: A 2-centre, observational, retrospective cohort study was performed. Inpatients using domperidone in 2 hospitals in the Netherlands during a period of 384 days before and after the media hype were included. The main outcomes were (1) the proportion of domperidone users with ECGs before and/or during domperidone treatment, (2) the proportion of patients with an ECG before and during treatment, and (3) the proportion of patients with an ECG during treatment. Secondary outcome was the proportion of domperidone prescriptions comparing the before- and after-period. RESULTS: Four hundred twenty-eight patients were included. The main outcomes [respectively (1) relative risk (RR) 1.02, 95% confidence interval (CI), 0.85-1.21; (2) RR 1.06, 95% CI, 0.60-1.85; and (3) RR 1.27, 95% CI, 0.80-2.01) were not different. After stratifying for hospital, no significant differences were found. A statistically significant decrease (RR 0.40, 95% CI, 0.35-0.45) in numbers of prescriptions was found for the university medical centre only. CONCLUSIONS: No effect of the media hype was found on the intensity of ECG monitoring in domperidone users. In the university medical centre, domperidone prescriptions were reduced.
PURPOSE: In March 2013, regulatory warnings concerning the potential risks of domperidone caused considerable media attention in the Netherlands. The aim of the study was to assess the effect of regulatory warnings and the resulting media hype on the frequency of electrocardiogram (ECG) monitoring of inpatients using domperidone. We also studied the effect on the frequency of prescribing domperidone by physicians. METHODS: A 2-centre, observational, retrospective cohort study was performed. Inpatients using domperidone in 2 hospitals in the Netherlands during a period of 384 days before and after the media hype were included. The main outcomes were (1) the proportion of domperidone users with ECGs before and/or during domperidone treatment, (2) the proportion of patients with an ECG before and during treatment, and (3) the proportion of patients with an ECG during treatment. Secondary outcome was the proportion of domperidone prescriptions comparing the before- and after-period. RESULTS: Four hundred twenty-eight patients were included. The main outcomes [respectively (1) relative risk (RR) 1.02, 95% confidence interval (CI), 0.85-1.21; (2) RR 1.06, 95% CI, 0.60-1.85; and (3) RR 1.27, 95% CI, 0.80-2.01) were not different. After stratifying for hospital, no significant differences were found. A statistically significant decrease (RR 0.40, 95% CI, 0.35-0.45) in numbers of prescriptions was found for the university medical centre only. CONCLUSIONS: No effect of the media hype was found on the intensity of ECG monitoring in domperidone users. In the university medical centre, domperidone prescriptions were reduced.
Authors: Irene Sarosiek; Mark Van Natta; Henry P Parkman; Thomas Abell; Kenneth L Koch; Braden Kuo; Robert J Shulman; Gianrico Farrugia; Madhusudan Grover; Frank A Hamilton; Pankaj J Pasricha; Katherine P Yates; Laura Miriel; Laura Wilson; Goro Yamada; James Tonascia; Richard W McCallum Journal: Clin Gastroenterol Hepatol Date: 2021-06-02 Impact factor: 11.382
Authors: Florine A Berger; Heleen van der Sijs; Matthijs L Becker; Teun van Gelder; Patricia M L A van den Bemt Journal: BMC Med Inform Decis Mak Date: 2020-07-23 Impact factor: 2.796