Literature DB >> 28921656

Animal models for studying the etiology and treatment of low back pain.

Changgui Shi1, Sujun Qiu2, Scott M Riester3, Vaskar Das4, Bingqian Zhu5, Atiyayein A Wallace4, Andre J van Wijnen3, Fackson Mwale6, James C Iatridis7, Daisuke Sakai8, Gina Votta-Velis9,10, Wen Yuan1, Hee-Jeong Im10,11.   

Abstract

Chronic low back pain is a major cause of disability and health care costs. Effective treatments are inadequate for many patients. Animal models are essential to further understanding of the pain mechanism and testing potential therapies. Currently, a number of preclinical models have been developed attempting to mimic aspects of clinical conditions that contribute to low back pain (LBP). This review focused on describing these animal models and the main behavioral tests for assessing pain in each model. Animal models of LBP can be divided into the following five categories: Discogenic LBP, radicular back pain, facet joint osteoarthritis back pain, muscle-induced LBP, and spontaneous occurring LBP models. These models are important not only for enhancing our knowledge of how LBP is generated, but also for the development of novel therapeutic regimens to treat LBP in patients.
© 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1305-1312, 2018. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

Entities:  

Keywords:  animal model; discogenic pain; dorsal root ganglia; low back pain; pain assessment; spinal cord

Mesh：

Year:  2018        PMID： 28921656      PMCID： PMC6287742          DOI： 10.1002/jor.23741

Source DB:  PubMed          Journal:  J Orthop Res        ISSN： 0736-0266            Impact factor:   3.494


  59 in total

Review 1.  Structural and functional brain abnormalities in chronic low back pain: A systematic review.

Authors:  Jeroen Kregel; Mira Meeus; Anneleen Malfliet; Mieke Dolphens; Lieven Danneels; Jo Nijs; Barbara Cagnie
Journal:  Semin Arthritis Rheum       Date:  2015-05-16       Impact factor: 5.532

2.  Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue.

Authors:  Meina Wang; Dezhi Tang; Bing Shu; Baoli Wang; Hongting Jin; Suyang Hao; Karen A Dresser; Jie Shen; Hee-Jeong Im; Erik R Sampson; Paul T Rubery; Michael J Zuscik; Edward M Schwarz; Regis J O'Keefe; Yongjun Wang; Di Chen
Journal:  Arthritis Rheum       Date:  2012-08

3.  Spinal glial activation and cytokine expression after lumbar root injury in the rat.

Authors:  H Hashizume; J A DeLeo; R W Colburn; J N Weinstein
Journal:  Spine (Phila Pa 1976)       Date:  2000-05-15       Impact factor: 3.468

4.  Chronic compartment syndrome in the erector spinae muscle.

Authors:  J Styf; E Lysell
Journal:  Spine (Phila Pa 1976)       Date:  1987-09       Impact factor: 3.468

5.  Gait abnormality due to spinal instability after lumbar facetectomy in the rat.

Authors:  Daisuke Fukui; Mamoru Kawakami; Munehito Yoshida; Shin-ichi Nakao; Toshiko Matsuoka; Hiroshi Yamada
Journal:  Eur Spine J       Date:  2014-09-04       Impact factor: 3.134

6.  Behavioral signs of chronic back pain in the SPARC-null mouse.

Authors:  Magali Millecamps; Maral Tajerian; E Helene Sage; Laura S Stone
Journal:  Spine (Phila Pa 1976)       Date:  2011-01-15       Impact factor: 3.468

7.  Experimental lumbar radiculopathy. Behavioral and histologic changes in a model of radicular pain after spinal nerve root irritation with chromic gut ligatures in the rat.

Authors:  M Kawakami; J N Weinstein; K Chatani; K F Spratt; S T Meller; G F Gebhart
Journal:  Spine (Phila Pa 1976)       Date:  1994-08-15       Impact factor: 3.468

Review 8.  Nonoperative management of discogenic back pain: a systematic review.

Authors:  Young Lu; Javier Z Guzman; Devina Purmessur; James C Iatridis; Andrew C Hecht; Sheeraz A Qureshi; Samuel K Cho
Journal:  Spine (Phila Pa 1976)       Date:  2014-07-15       Impact factor: 3.468

9.  Assessment of pain behavior in a rat model of intervertebral disc injury using the CatWalk gait analysis system.

Authors:  Masayuki Miyagi; Tetsuhiro Ishikawa; Hiroto Kamoda; Miyako Suzuki; Yoshihiro Sakuma; Sumihisa Orita; Yasuhiro Oikawa; Yasuchika Aoki; Tomoaki Toyone; Kazuhisa Takahashi; Gen Inoue; Seiji Ohtori
Journal:  Spine (Phila Pa 1976)       Date:  2013-08-01       Impact factor: 3.468

10.  Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy.

Authors:  Mohammed F Shamji; Kyle D Allen; Stephen So; Liufang Jing; Samuel B Adams; Reinhard Schuh; Janet Huebner; Virginia B Kraus; Allan H Friedman; Lori A Setton; William J Richardson
Journal:  Spine (Phila Pa 1976)       Date:  2009-04-01       Impact factor: 3.468
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  17 in total

1.  Disc degeneration spreads: long-term behavioural, histologic and radiologic consequences of a single-level disc injury in active and sedentary mice.

Authors:  Magali Millecamps; Seunghwan Lee; Daniel Z Foster; Laura S Stone
Journal:  Eur Spine J       Date:  2021-07-03       Impact factor: 3.134

2.  Sex-Related Pain Behavioral Differences following Unilateral NGF Injections in a Rat Model of Low Back Pain.

Authors:  Michael Syrett; Nicholas R Reed; William R Reed; Madison L Richey; Andrey Frolov; Joshua W Little
Journal:  Biology (Basel)       Date:  2022-06-16

3.  Associations of Lumber Disc Degeneration With Paraspinal Muscles Myosteatosis in Discogenic Low Back Pain.

Authors:  Yilong Huang; Ling Wang; Baofa Luo; Kaiwen Yang; Xiaomin Zeng; Jiaxin Chen; Zhenguang Zhang; Yanlin Li; Xiaoguang Cheng; Bo He
Journal:  Front Endocrinol (Lausanne)       Date:  2022-05-13       Impact factor: 6.055

Review 4.  Innovations and advances in modelling and measuring pain in animals.

Authors:  Katelyn E Sadler; Jeffrey S Mogil; Cheryl L Stucky
Journal:  Nat Rev Neurosci       Date:  2021-11-26       Impact factor: 38.755

5.  Nanofibrous spongy microspheres to deliver rabbit mesenchymal stem cells and anti-miR-199a to regenerate nucleus pulposus and prevent calcification.

Authors:  Ganjun Feng; Zhanpeng Zhang; Ming Dang; Kunal J Rambhia; Peter X Ma
Journal:  Biomaterials       Date:  2020-06-21       Impact factor: 12.479

Review 6.  Chronic low back pain: a mini-review on pharmacological management and pathophysiological insights from clinical and pre-clinical data.

Authors:  Thomas S W Park; Andy Kuo; Maree T Smith
Journal:  Inflammopharmacology       Date:  2018-05-12       Impact factor: 4.473

7.  Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain.

Authors:  Pradeep Suri; Melody R Palmer; Yakov A Tsepilov; Maxim B Freidin; Cindy G Boer; Michelle S Yau; Daniel S Evans; Andrea Gelemanovic; Traci M Bartz; Maria Nethander; Liubov Arbeeva; Lennart Karssen; Tuhina Neogi; Archie Campbell; Dan Mellstrom; Claes Ohlsson; Lynn M Marshall; Eric Orwoll; Andre Uitterlinden; Jerome I Rotter; Gordan Lauc; Bruce M Psaty; Magnus K Karlsson; Nancy E Lane; Gail P Jarvik; Ozren Polasek; Marc Hochberg; Joanne M Jordan; Joyce B J Van Meurs; Rebecca Jackson; Carrie M Nielson; Braxton D Mitchell; Blair H Smith; Caroline Hayward; Nicholas L Smith; Yurii S Aulchenko; Frances M K Williams
Journal:  PLoS Genet       Date:  2018-09-27       Impact factor: 6.020

8.  Interleukin-8 as a therapeutic target for chronic low back pain: Upregulation in human cerebrospinal fluid and pre-clinical validation with chronic reparixin in the SPARC-null mouse model.

Authors:  Emerson Krock; Magali Millecamps; Kathleen M Anderson; Akanksha Srivastava; Troy E Reihsen; Pawan Hari; Yue Ran Sun; Seon Ho Jang; George L Wilcox; Kumar G Belani; David S Beebe; Jean Ouellet; Manuel R Pinto; Lois J Kehl; Lisbet Haglund; Laura S Stone
Journal:  EBioMedicine       Date:  2019-04-30       Impact factor: 8.143

Review 9.  Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS spine section.

Authors:  Lachlan J Smith; Lara Silverman; Daisuke Sakai; Christine L Le Maitre; Robert L Mauck; Neil R Malhotra; Jeffrey C Lotz; Conor T Buckley
Journal:  JOR Spine       Date:  2018-10-08

10.  Grand Challenges in Musculoskeletal Pain Research: Chronicity, Comorbidity, Immune Regulation, Sex Differences, Diagnosis, and Treatment Opportunities.

Authors:  Ke Ren
Journal:  Front Pain Res (Lausanne)       Date:  2020-10-23
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