| Literature DB >> 2892109 |
T Shibasaki1, Y S Kim, N Yamauchi, A Masuda, T Imaki, M Hotta, H Demura, I Wakabayashi, N Ling, K Shizume.
Abstract
The effect of somatostatin on corticotropin-releasing factor (CRF)-induced anorexia was examined in rats. Intracerebroventricular (icv) administration of 0.11 nmol and 0.21 nmol ovine CRF significantly suppressed food intake of 24 h-starved rats. Icv administration of 0.31 nmol somatostatin 14 and somatostatin 28 partially reversed suppression of food intake induced by icv injection of 0.21 nmol CRF in 24 h-starved rats. These results suggest that somatostatin may counteract the suppressive effect of CRF on food intake within the central nervous system.Entities:
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Year: 1988 PMID: 2892109 DOI: 10.1016/0024-3205(88)90642-x
Source DB: PubMed Journal: Life Sci ISSN: 0024-3205 Impact factor: 5.037