| Literature DB >> 28920861 |
Jagriti Upadhyay1, Stergios A Polyzos2, Nikolaos Perakakis3, Bindiya Thakkar4, Stavroula A Paschou5, Niki Katsiki6, Patricia Underwood4, Kyung-Hee Park7, Jochen Seufert8, Eun Seok Kang9, Elliot Sternthal4, Asterios Karagiannis2, Christos S Mantzoros10.
Abstract
Type 2 diabetes (T2DM) is a leading cause of morbidity and mortality worldwide and a major economic burden. The prevalence of T2DM is rising, suggesting more effective prevention and treatment strategies are necessary. The aim of this narrative review is to summarize the pharmacologic treatment options available for patients with T2DM. Each therapeutic class is presented in detail, outlining medication effects, side effects, glycemic control, effect on weight, indications and contraindications, and use in selected populations (heart failure, renal insufficiency, obesity and the elderly). We also present representative cost for each antidiabetic category. Then, we provide an individualized guide for initiation and intensification of treatment and discuss the considerations and rationale for an individualized glycemic goal.Entities:
Keywords: Algorithm; Goals pharmacotherapy; Personalized therapy; Type 2 diabetes
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Year: 2017 PMID： 28920861 DOI： 10.1016/j.metabol.2017.08.010
Source DB: PubMed Journal: Metabolism ISSN： 0026-0495 Impact factor: 8.694