Literature DB >> 28920612

Visible-light-mediated oxidative demethylation of N6-methyl adenines.

Li-Jun Xie1, Rui-Li Wang, Dong Wang, Li Liu, Liang Cheng.   

Abstract

We report a simple protocol that affords oxidative demethylation of N6-methyl groups in N6-methyl adenines (m6A). The biologically compatible photocatalyst riboflavin prompts a highly selective C-H abstraction from N6-methyl in adenines under the irradiation of a visible blue LED light, affording a novel and highly selective biomimetic demethylation of m6A and related N-methyl adenine analogues.

Entities:  

Year:  2017        PMID： 28920612     DOI： 10.1039/c7cc05544g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Collateral Damage Occurs When Using Photosensitizer Probes to Detect or Modulate Nucleic Acid Modifications.

Authors:  Aaron M Fleming; Michael B Chabot; Ngoc L B Nguyen; Cynthia J Burrows
Journal:  Angew Chem Int Ed Engl       Date:  2021-12-29       Impact factor: 15.336

Review 2.  N-Dealkylation of Amines.

Authors:  Ali Alipour Najmi; Rainer Bischoff; Hjalmar P Permentier
Journal:  Molecules       Date:  2022-05-20       Impact factor: 4.927

3.  Selective Chemical Functionalization at N6-Methyladenosine Residues in DNA Enabled by Visible-Light-Mediated Photoredox Catalysis.

Authors:  Manuel Nappi; Alexandre Hofer; Shankar Balasubramanian; Matthew J Gaunt
Journal:  J Am Chem Soc       Date:  2020-12-11       Impact factor: 15.419

Review 4.  Implications of m6A methylation and microbiota interaction in non-small cell lung cancer: From basics to therapeutics.

Authors:  Fen-Sheng Qiu; Jia-Qi He; Yu-Sen Zhong; Mei-Ying Guo; Chen-Huan Yu
Journal:  Front Cell Infect Microbiol       Date:  2022-09-02       Impact factor: 6.073

5.  The Influence of the Degradation of Tetracycline by Free Radicals from Riboflavin-5'-Phosphate Photolysis on Microbial Viability.

Authors:  Shiuh-Tsuen Huang; Shwu-Yuan Lee; Song-Hua Wang; Chun-Yi Wu; Jeu-Ming P Yuann; Sin He; Chien-Wei Cheng; Ji-Yuan Liang
Journal:  Microorganisms       Date:  2019-10-28
  5 in total

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