| Literature DB >> 28920481 |
Giulia Gigliarelli1, Claudia Zadra1, Lina Cossignani1, Ramon Enrique Robles Zepeda2, Luisa Alondra Rascón-Valenzuela2, Carlos Arturo Velázquez-Contreras2, Maria Carla Marcotullio1.
Abstract
Two new lignans, namely 7-O-podophyllotoxinyl butyrate (1) and dihydroclusin 9-acetate (2), were isolated from the dichloromethane fraction of a methanol extract of Bursera microphylla (Burseraceae), along with eight known lignans (3-10). Their structures were determined by means of comprehensive spectroscopic analysis. Lignans 2-6 were tested for their anti-proliferative activity on the cancer cell lines LS180, A549 and HeLa, and on a non-cancer cell line, ARPE-19. Only compounds 4 and 5 showed an interesting activity on HeLa cells.Entities:
Keywords: 7-O-podophyllotoxinyl butyrate; Burseraceae; anti-proliferative activity; dihydroclusin 9-acetate; lignans
Mesh：
Substances：
Year: 2017 PMID： 28920481 DOI： 10.1080/14786419.2017.1375922
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861