Kyung Jong Lee1, Man Pyo Chung1, Young Whan Kim1, Jae Ho Lee1, Kyu-Sik Kim1, Jeong Seon Ryu1, Hong Lyeol Lee1, Sung Woo Park1, Choon Sik Park1, Soo-Tak Uh1, Yong Chul Lee1, Seoung Ju Park1, Kwan Hyoung Kim1, Young June Jeon1, Won Il Choi1, Yong Bum Park1, Dong Soon Kim1, Sung Hwan Jeong1, Jin Hwa Lee1, Moo Suk Park1. 1. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Internal Medicine, Seoul National University College of Medicine, South Korea Department of Internal Medicine, Chonnam National University College of Medicine, South Korea Department of Internal Medicine, Inha University College of Medicine, South Korea Department of Internal Medicine, Soon Chun Hyang University College of Medicine, South Korea Department of Internal Medicine, Chonbuk National University College of Medicine, South Korea Department of Internal Medicine, Catholic University College of Medicine, South Korea Department of Internal Medicine, Keimyung University School of Medicine, South Korea Department of Internal Medicine, Hallym University College of Medicine, South Korea Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan, South Korea Department of Internal Medicine, Gachon University College of Medicine, South Korea Department of Internal Medicine, Ewha Womans University College of Medicine, South Korea Department of Internal Medicine, Yonsei University College of Medicine, South Korea.
Abstract
BACKGROUND: The aim of this study was to evaluate the prevalence, risk factors, and survival of lung cancer in patients with idiopathic pulmonary fibrosis (IPF). METHODS: IPF with lung cancer from tertiary hospitals consisted of 1685 patients who had been diagnosed between 2003 and 2007. We reviewed their medical records retrospectively to evaluate the prevalence, risk factors and prognosis of lung cancer in IPF patients. RESULTS: Among all patients with IPF, 114 cases (6.8%) had lung cancer with IPF. The incidence of lung cancer in patients with IPF was 1.03 persons per 100 person-year (25 patients/2408 years). Most cases of lung cancer (73/114, 68.9%) were located in IPF-associated areas; the lung cancer typically developed in peripheral and lower lobe areas. The study revealed that forced vital capacity (% predicted) at the initial diagnosis and development of lung cancer were independent prognostic factors in patients with IPF. CONCLUSIONS: Lung cancer in patients with IPF was significantly related with the IPF prognosis. An active evaluation should be performed in patients with IPF to detect lung cancer early.
BACKGROUND: The aim of this study was to evaluate the prevalence, risk factors, and survival of lung cancer in patients with idiopathic pulmonary fibrosis (IPF). METHODS: IPF with lung cancer from tertiary hospitals consisted of 1685 patients who had been diagnosed between 2003 and 2007. We reviewed their medical records retrospectively to evaluate the prevalence, risk factors and prognosis of lung cancer in IPF patients. RESULTS: Among all patients with IPF, 114 cases (6.8%) had lung cancer with IPF. The incidence of lung cancer in patients with IPF was 1.03 persons per 100 person-year (25 patients/2408 years). Most cases of lung cancer (73/114, 68.9%) were located in IPF-associated areas; the lung cancer typically developed in peripheral and lower lobe areas. The study revealed that forced vital capacity (% predicted) at the initial diagnosis and development of lung cancer were independent prognostic factors in patients with IPF. CONCLUSIONS:Lung cancer in patients with IPF was significantly related with the IPF prognosis. An active evaluation should be performed in patients with IPF to detect lung cancer early.
Authors: SongYi Han; Yeon Joo Lee; Jong Sun Park; Young-Jae Cho; Ho Il Yoon; Jae-Ho Lee; Choon-Taek Lee; Jin-Haeng Chung; Kyung Won Lee; Sang Hoon Lee Journal: Sci Rep Date: 2019-08-29 Impact factor: 4.379