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Literature DB >> 28919920

Virulence determinants of West Nile virus: how can these be used for vaccine design?

Jaclyn A Kaiser^1,1, Tian Wang^1,2,3,1,2,3, Alan Dt Barrett^1,2,3,1,2,3.

Abstract

West Nile virus (WNV), a neurotropic mosquito-borne flavivirus, has become endemic in the USA and parts of Europe since 1999. There is no licensed WNV vaccine for humans. Considering the robust immunity from immunization with live, attenuated vaccines, a live WNV vaccine is an ideal platform for disease control. Animal and mosquito studies have identified a number of candidate attenuating mutations, including the structural proteins premembrane/membrane and envelope, and the nonstructural proteins NS1, NS2A, NS3, NS4A, NS4B and NS5, and the 3' UTR. Many of the mutations that have been examined attenuate WNV using different mechanisms, thus providing a greater understanding of WNV virulence while also identifying specific mutations as candidates to include in a WNV live vaccine.

Entities: Disease Gene Species

Keywords: West Nile virus; attenuation; flavivirus; live attenuated vaccine; virulence

Year: 2017 PMID： 28919920 PMCID： PMC5592643 DOI： 10.2217/fvl-2016-0141

Source DB: PubMed Journal: Future Virol ISSN： 1746-0794 Impact factor: 1.831

59 in total

1. Genetic Determinants of Japanese Encephalitis Virus Vaccine Strain SA14-14-2 That Govern Attenuation of Virulence in Mice.

Authors: Gregory D Gromowski; Cai-Yen Firestone; Stephen S Whitehead
Journal: J Virol Date: 2015-04-08 Impact factor: 5.103

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Journal: Ann N Y Acad Sci Date: 2001-12 Impact factor: 5.691

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Authors: Bimmi Shrestha; Melanie A Samuel; Michael S Diamond
Journal: J Virol Date: 2006-01 Impact factor: 5.103

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Authors: Thomas Welte; Guorui Xie; Jason A Wicker; Melissa C Whiteman; Li Li; Aparna Rachamallu; Alan Barrett; Tian Wang
Journal: Vaccine Date: 2011-05-05 Impact factor: 3.641

5. Genetic and phenotypic variation of West Nile virus in New York, 2000-2003.

Authors: Gregory D Ebel; Justin Carricaburu; David Young; Kristen A Bernard; Laura D Kramer
Journal: Am J Trop Med Hyg Date: 2004-10 Impact factor: 2.345

6. B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus.

Authors: Michael S Diamond; Bimmi Shrestha; Anantha Marri; Darby Mahan; Michael Engle
Journal: J Virol Date: 2003-02 Impact factor: 5.103

Review 7. The structural immunology of antibody protection against West Nile virus.

Authors: Michael S Diamond; Theodore C Pierson; Daved H Fremont
Journal: Immunol Rev Date: 2008-10 Impact factor: 12.988

Review 8. Molecular epidemiology and evolution of West Nile virus in North America.

Authors: Brian R Mann; Allison R McMullen; Daniele M Swetnam; Alan D T Barrett
Journal: Int J Environ Res Public Health Date: 2013-10-16 Impact factor: 3.390

Review 9. Noncoding subgenomic flavivirus RNA: multiple functions in West Nile virus pathogenesis and modulation of host responses.

Authors: Justin A Roby; Gorben P Pijlman; Jeffrey Wilusz; Alexander A Khromykh
Journal: Viruses Date: 2014-01-27 Impact factor: 5.048