Anthony Buisson1, Bruno Pereira2, Marion Goutte3, Maud Reymond4, Christophe Allimant4, Hélène Obritin-Guilhen3, Gilles Bommelaer3, Constance Hordonneau5. 1. Clermont Auvergne University, Inserm, 3iHP, CHU Clermont-Ferrand, Gastroenterology Department, IBD Unit, Clermont-Ferrand, France; Clermont Auvergne University, Inserm U1071, M2iSH, USC-INRA 2018, Clermont-Ferrand, France. Electronic address: a_buisson@hotmail.fr. 2. Clermont Auvergne University, CHU Clermont-Ferrand, DRCI, Bisotatistics Unit, Clermont-Ferrand, France. 3. Clermont Auvergne University, Inserm, 3iHP, CHU Clermont-Ferrand, Gastroenterology Department, IBD Unit, Clermont-Ferrand, France; Clermont Auvergne University, Inserm U1071, M2iSH, USC-INRA 2018, Clermont-Ferrand, France. 4. Clermont Auvergne University, Inserm, 3iHP, CHU Clermont-Ferrand, Gastroenterology Department, IBD Unit, Clermont-Ferrand, France. 5. Clermont Auvergne University, CHU Clermont-Ferrand, Radiology Unit, Clermont-Ferrand, France.
Abstract
BACKGROUND: Magnetic resonance index of activity (MaRIA) and Clermont score are currently the two main MRI indices that have been validated compared to endoscopy in Crohn's disease (CD). AIMS: To compare the accuracy of MaRIA and Clermont score in assessing CD mucosal healing. METHODS: Fourty-four CD patients underwent prospectively and consecutively MRI and colonoscopy. RESULTS: Considering 207 segments, MaRIA>7 and Clermont score>8.4 demonstrated substantial accuracy to detect endoscopic ulcerations (73.9% and 74.0%, respectively) and presented with high specificity (82.1% and 81.3%) and high negative predictive value (NPV) (82.1% and 82.4%) for MaRIA and Clermont score, respectively. The sensitivity for detecting deep ulcerations was 90.9% for both MaRIA>11 and Clermont score>12.5, with a specificity of 82.0% and 80.0%, respectively. Among 44 patients, deep MRI remission predicted mucosal healing with specificity=85.3% and NPV=85.3% according to Barcelona criteria (no segmental MaRIA>7), and specificity=88.2% and NPV=85.7% according to Clermont criteria (no segmental Clermont score>8.4). In addition, MRI remission predicted mucosal healing with specificity=76.5% and NPV=86.7% according to Barcelona criteria (no segmental MaRIA>11), and specificity=79.4% and NPV=84.4% according to Clermont criteria (no segmental Clermont score>12.5). CONCLUSION: MaRIA and Clermont score are equally effective in detecting CD endoscopic ulcerations supporting their use as therapeutic endpoints.
BACKGROUND: Magnetic resonance index of activity (MaRIA) and Clermont score are currently the two main MRI indices that have been validated compared to endoscopy in Crohn's disease (CD). AIMS: To compare the accuracy of MaRIA and Clermont score in assessing CD mucosal healing. METHODS: Fourty-four CDpatients underwent prospectively and consecutively MRI and colonoscopy. RESULTS: Considering 207 segments, MaRIA>7 and Clermont score>8.4 demonstrated substantial accuracy to detect endoscopic ulcerations (73.9% and 74.0%, respectively) and presented with high specificity (82.1% and 81.3%) and high negative predictive value (NPV) (82.1% and 82.4%) for MaRIA and Clermont score, respectively. The sensitivity for detecting deep ulcerations was 90.9% for both MaRIA>11 and Clermont score>12.5, with a specificity of 82.0% and 80.0%, respectively. Among 44 patients, deep MRI remission predicted mucosal healing with specificity=85.3% and NPV=85.3% according to Barcelona criteria (no segmental MaRIA>7), and specificity=88.2% and NPV=85.7% according to Clermont criteria (no segmental Clermont score>8.4). In addition, MRI remission predicted mucosal healing with specificity=76.5% and NPV=86.7% according to Barcelona criteria (no segmental MaRIA>11), and specificity=79.4% and NPV=84.4% according to Clermont criteria (no segmental Clermont score>12.5). CONCLUSION: MaRIA and Clermont score are equally effective in detecting CD endoscopic ulcerations supporting their use as therapeutic endpoints.
Authors: Bruno Cunha Fialho Cantarelli; Rafael Santiago de Oliveira; Aldo Maurici Araújo Alves; Bruno Jucá Ribeiro; Fernanda Velloni; Giuseppe D'Ippolito Journal: Radiol Bras Date: 2020 Jan-Feb
Authors: James Gauci; Lara Sammut; Martina Sciberras; Naomi Piscopo; Kristian Micallef; Kelvin Cortis; Pierre Ellul Journal: Ann Gastroenterol Date: 2018-05-04