Literature DB >> 28917289

Imaging of Convective Drug Delivery in the Nervous System.

Russell R Lonser1.   

Abstract

Convection-enhanced delivery permits the direct homogeneous delivery of small- and large-molecular-weight putative therapeutics to the nervous system in a manner that bypasses the blood-nervous system barrier. The development of co-infused surrogate imaging tracers (for computed tomography and MRI) allows for the real-time, noninvasive monitoring of infusate distribution during convective delivery. Real-time image monitoring of convective distribution of therapeutic agents insures that targeted structures/nervous system regions are adequately perfused, enhances safety, informs efficacy (or lack thereof) of putative agents, and provides critical information regarding the properties of convection-enhanced delivery in normal and various pathologic tissue states. Published by Elsevier Inc.

Entities:  

Keywords:  Convection-enhanced delivery; Drug delivery; Imaging; Infusion; Nervous system; Surrogate imaging tracer

Mesh：

Year:  2017        PMID： 28917289      PMCID： PMC5651089          DOI： 10.1016/j.nec.2017.05.012

Source DB:  PubMed          Journal:  Neurosurg Clin N Am        ISSN： 1042-3680            Impact factor:   2.509


  51 in total

1.  Imaging-guided convection-enhanced delivery and gene therapy of glioblastoma.

Authors:  Juergen Voges; Regina Reszka; Axel Gossmann; Claus Dittmar; Raphaela Richter; Guido Garlip; Lutz Kracht; Heinz H Coenen; Volker Sturm; Karl Wienhard; Wolf-Dieter Heiss; Andreas H Jacobs
Journal:  Ann Neurol       Date:  2003-10       Impact factor: 10.422

Review 2.  New methods of drug delivery.

Authors:  R Langer
Journal:  Science       Date:  1990-09-28       Impact factor: 47.728

3.  A dual CT-MR dendrimer contrast agent as a surrogate marker for convection-enhanced delivery of intracerebral macromolecular therapeutic agents.

Authors:  Celeste Aida S Regino; Stuart Walbridge; Marcelino Bernardo; Karen J Wong; Dennis Johnson; Russell Lonser; Edward H Oldfield; Peter L Choyke; Martin W Brechbiel
Journal:  Contrast Media Mol Imaging       Date:  2008 Jan-Feb       Impact factor: 3.161

4.  Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain.

Authors:  R Mark Richardson; Adrian P Kells; Alastair J Martin; Paul S Larson; Philip A Starr; Peter G Piferi; Geoffrey Bates; Lisa Tansey; Kathryn H Rosenbluth; John R Bringas; Mitchel S Berger; Krystof S Bankiewicz
Journal:  Stereotact Funct Neurosurg       Date:  2011-04-14       Impact factor: 1.875

Review 5.  Immunologic privilege in the central nervous system and the blood-brain barrier.

Authors:  Leslie L Muldoon; Jorge I Alvarez; David J Begley; Ruben J Boado; Gregory J Del Zoppo; Nancy D Doolittle; Britta Engelhardt; John M Hallenbeck; Russell R Lonser; John R Ohlfest; Alexandre Prat; Maurizio Scarpa; Richard J Smeyne; Lester R Drewes; Edward A Neuwelt
Journal:  J Cereb Blood Flow Metab       Date:  2012-10-17       Impact factor: 6.200

6.  Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease.

Authors:  R Mark Richardson; Adrian P Kells; Kathryn H Rosenbluth; Ernesto Aguilar Salegio; Massimo S Fiandaca; Paul S Larson; Philip A Starr; Alastair J Martin; Russell R Lonser; Howard J Federoff; John R Forsayeth; Krystof S Bankiewicz
Journal:  Mol Ther       Date:  2011-02-22       Impact factor: 11.454

7.  High-flow microinfusion: tissue penetration and pharmacodynamics.

Authors:  P F Morrison; D W Laske; H Bobo; E H Oldfield; R L Dedrick
Journal:  Am J Physiol       Date:  1994-01

8.  Convection-enhanced delivery of macromolecules in the brain.

Authors:  R H Bobo; D W Laske; A Akbasak; P F Morrison; R L Dedrick; E H Oldfield
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-15       Impact factor: 11.205

9.  Poor drug distribution as a possible explanation for the results of the PRECISE trial.

Authors:  John H Sampson; Gary Archer; Christoph Pedain; Eva Wembacher-Schröder; Manfred Westphal; Sandeep Kunwar; Michael A Vogelbaum; April Coan; James E Herndon; Raghu Raghavan; Martin L Brady; David A Reardon; Allan H Friedman; Henry S Friedman; M Inmaculada Rodríguez-Ponce; Susan M Chang; Stephan Mittermeyer; David Croteau; Raj K Puri
Journal:  J Neurosurg       Date:  2010-08       Impact factor: 5.115

10.  Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain.

Authors:  Ryuta Saito; Michal T Krauze; John R Bringas; Charles Noble; Tracy R McKnight; Pamela Jackson; Michael F Wendland; Christoph Mamot; Daryl C Drummond; Dimitri B Kirpotin; Keelung Hong; Mitchel S Berger; John W Park; Krystof S Bankiewicz
Journal:  Exp Neurol       Date:  2005-09-28       Impact factor: 5.330
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  1 in total

Review 1.  Insights into Infusion-Based Targeted Drug Delivery in the Brain: Perspectives, Challenges and Opportunities.

Authors:  Asad Jamal; Tian Yuan; Stefano Galvan; Antonella Castellano; Marco Riva; Riccardo Secoli; Andrea Falini; Lorenzo Bello; Ferdinando Rodriguez Y Baena; Daniele Dini
Journal:  Int J Mol Sci       Date:  2022-03-15       Impact factor: 5.923
  1 in total

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