Nuno Adubeiro1, Maria Luísa Nogueira2, Rita G Nunes3, Hugo Alexandre Ferreira4, Eduardo Ribeiro5, José Maria Ferreira La Fuente6. 1. Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; Department of Radiology, School of Health of Porto/Polytechnic Institute of Porto (ESS/IPP), Rua Dr. António Bernardino de Almeida 400, 4200-072 Porto, Portugal. Electronic address: nca@eu.ipp.pt. 2. Department of Radiology, School of Health of Porto/Polytechnic Institute of Porto (ESS/IPP), Rua Dr. António Bernardino de Almeida 400, 4200-072 Porto, Portugal. 3. Institute for Systems and Robotics and Department of Bioengineering, LARSyS, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal. 4. Institute of Biophysics and Biomedical Engineering (IBEB), Faculty of Sciences, University of Lisbon, Campo Grande, 1749-016 Lisboa, Portugal. 5. Department of Radiology, MRI Unit, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 4099-001 Porto, Portugal; Department of Radiology, School of Health of Porto (ESS), Rua Dr. António Bernardino de Almeida 400, 4200-072 Porto, Portugal. 6. Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; Department of Urology, Center Hospitalar Porto (CHP), Largo Prof. Abel Salazar, 4099-001 Porto, Portugal.
Abstract
PURPOSE: Determining optimal b-value pair for differentiation between normal and prostate cancer (PCa) tissues. METHODS: Forty-three patients with diagnosis or PCa symptoms were included. Apparent diffusion coefficient (ADC) was estimated using minimum and maximum b-values of 0, 50, 100, 150, 200, 500s/mm2 and 500, 800, 1100, 1400, 1700 and 2000s/mm2, respectively. Diagnostic performances were evaluated when Area-under-the-curve (AUC)>95%. RESULTS: 15 of the 35 b-values pair surpassed this AUC threshold. The pair (50, 2000s/mm2) provided the highest AUC (96%) with ADC cutoff 0.89×10-3mm2/s, sensitivity 95.5%, specificity 93.2% and accuracy 94.4%. CONCLUSIONS: The best b-value pair was b=50, 2000s/mm2.
PURPOSE: Determining optimal b-value pair for differentiation between normal and prostate cancer (PCa) tissues. METHODS: Forty-three patients with diagnosis or PCa symptoms were included. Apparent diffusion coefficient (ADC) was estimated using minimum and maximum b-values of 0, 50, 100, 150, 200, 500s/mm2 and 500, 800, 1100, 1400, 1700 and 2000s/mm2, respectively. Diagnostic performances were evaluated when Area-under-the-curve (AUC)>95%. RESULTS: 15 of the 35 b-values pair surpassed this AUC threshold. The pair (50, 2000s/mm2) provided the highest AUC (96%) with ADC cutoff 0.89×10-3mm2/s, sensitivity 95.5%, specificity 93.2% and accuracy 94.4%. CONCLUSIONS: The best b-value pair was b=50, 2000s/mm2.
Authors: David D B Bates; Jennifer S Golia Pernicka; James L Fuqua; Viktoriya Paroder; Iva Petkovska; Junting Zheng; Marinela Capanu; Juliana Schilsky; Marc J Gollub Journal: Abdom Radiol (NY) Date: 2020-02
Authors: Chris Dulhanty; Linda Wang; Maria Cheng; Hayden Gunraj; Farzad Khalvati; Masoom A Haider; Alexander Wong Journal: Sensors (Basel) Date: 2020-03-10 Impact factor: 3.576