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Literature DB >> 2891614

The same MHC recombinational hot spots are active in crossing-over between wild/wild and wild/inbred mouse chromosomes.

Y Uematsu¹, K Fischer Lindahl, M Steinmetz.

Abstract

Four recombinational breakpoints were mapped in the K-A interval of the mouse major histocompatibility complex (MHC) by Southern blot analysis. The breakpoint in B10.SBR, containing a b/s recombinant MHC haplotype, is located about 45 kb upstream of the A beta 2 gene close to the breakpoint in B10.AQR. Crossover in two cas3/cas4 and one cas4/cas3 recombinant haplotypes has taken place in the previously identified K/A beta 3 and A beta 3/A beta 2 recombinational hot spots. The same hot spots are thus active in crossover between two Mus musculus castaneus MHC haplotypes and in crossover between a laboratory and a M. m. castaneus MHC haplotype.

Entities: Gene Species

Mesh：

Substances：
DNA Restriction Enzymes

Year: 1988 PMID： 2891614 DOI： 10.1007/bf00351082

Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846

16 in total

1. Molecular mapping of murine I region recombinants: crossing over in the E beta gene.

Authors: B K Saha; S E Cullen
Journal: J Immunol Date: 1986-02-01 Impact factor: 5.422

2. Recombination hot spots within the I region of the mouse H-2 complex map to the E beta and E alpha genes.

Authors: W P Lafuse; C S David
Journal: Immunogenetics Date: 1986 Impact factor: 2.846

3. Eight new MHC recombinant strains defining at least six H-2 haplotypes.

Authors: S L Epstein; J S Arn; D H Sachs
Journal: Immunogenetics Date: 1986 Impact factor: 2.846

4. Sexual preference of meiotic recombination within the H-2 complex.

Authors: T Shiroishi; T Sagai; K Moriwaki
Journal: Immunogenetics Date: 1987 Impact factor: 2.846

5. Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens.

Authors: V T Oi; P P Jones; J W Goding; L A Herzenberg; L A Herzenberg
Journal: Curr Top Microbiol Immunol Date: 1978 Impact factor: 4.291

6. Molecular mapping of crossover sites within the I region of the mouse MHC. Analysis of ten recombinant chromosomes.

Authors: E J Zimmerer; E Ogin; D C Shreffler; H C Passmore
Journal: Immunogenetics Date: 1987 Impact factor: 2.846

7. A molecular map of the immune response region from the major histocompatibility complex of the mouse.

Authors: M Steinmetz; K Minard; S Horvath; J McNicholas; J Srelinger; C Wake; E Long; B Mach; L Hood
Journal: Nature Date: 1982-11-04 Impact factor: 49.962

8. Free Ia E alpha chain expression in the E+ alpha : E- beta recombinant strain A.TFR5.

Authors: A B Begovich; P P Jones
Journal: Immunogenetics Date: 1985 Impact factor: 2.846

9. Gene organization and recombinational hotspots in the murine major histocompatibility complex.

Authors: M Steinmetz; D Stephan; K Fischer Lindahl
Journal: Cell Date: 1986-03-28 Impact factor: 41.582

10. Mta, the maternally transmitted antigen, is determined jointly by the chromosomal Hmt and the extrachromosomal Mtf genes.

Authors: K F Lindahl; B Hausmann; P J Robinson; J L Guénet; D C Wharton; H Winking
Journal: J Exp Med Date: 1986-02-01 Impact factor: 14.307

11 in total

1. Multiple sites of crossing over within the Eb recombinational hotspot in the mouse.

Authors: E C Bryda; J A DePari; D B Sant'Angelo; D B Murphy; H C Passmore
Journal: Mamm Genome Date: 1992 Impact factor: 2.957

2. A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex.

Authors: S Cho; M Attaya; M G Brown; J J Monaco
Journal: Proc Natl Acad Sci U S A Date: 1991-06-15 Impact factor: 11.205

3. DNase I-hypersensitive sites and transcription factor-binding motifs within the mouse E beta meiotic recombination hot spot.

Authors: R Shenkar; M H Shen; N Arnheim
Journal: Mol Cell Biol Date: 1991-04 Impact factor: 4.272

The same MHC recombinational hot spots are active in crossing-over between wild/wild and wild/inbred mouse chromosomes.

1. Molecular mapping of murine I region recombinants: crossing over in the E beta gene.

2. Recombination hot spots within the I region of the mouse H-2 complex map to the E beta and E alpha genes.

3. Eight new MHC recombinant strains defining at least six H-2 haplotypes.

4. Sexual preference of meiotic recombination within the H-2 complex.

5. Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens.

6. Molecular mapping of crossover sites within the I region of the mouse MHC. Analysis of ten recombinant chromosomes.

7. A molecular map of the immune response region from the major histocompatibility complex of the mouse.

8. Free Ia E alpha chain expression in the E+ alpha : E- beta recombinant strain A.TFR5.

9. Gene organization and recombinational hotspots in the murine major histocompatibility complex.

10. Mta, the maternally transmitted antigen, is determined jointly by the chromosomal Hmt and the extrachromosomal Mtf genes.

1. Multiple sites of crossing over within the Eb recombinational hotspot in the mouse.

2. A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex.

3. DNase I-hypersensitive sites and transcription factor-binding motifs within the mouse E beta meiotic recombination hot spot.

4. Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

5. Molecular mapping of a recombination hotspot located in the second intron of the human TAP2 locus.

6. The minimal polymorphism of class II E alpha chains is not due to the functional neutrality of mutations.

7. Discordant patterns of linkage disequilibrium of the peptide-transporter loci within the HLA class II region.

8. Molecular basis of genetic polymorphism in major histocompatibility complex-linked proteasome gene (Lmp-2).

9. No dosage effect of recombinational hotspots in the mouse major histocompatibility complex.

10. Recombination in the class III region of the mouse major histocompatibility complex.