Literature DB >> 2891567

Clostridium perfringens iota toxin ADP-ribosylates skeletal muscle actin in Arg-177.

J Vandekerckhove1, B Schering, M Bärmann, K Aktories.   

Abstract

Clostridium perfringens iota toxin ADP-ribosylates actin. Substrates of C. perfringens toxin are both non-muscle beta/gamma-actin and skeletal muscle actin. This finding suggests that C. perfringens iota ADP-ribosylates the same amino acid in skeletal muscle and non-muscle actin as does C. botulinum C2 toxin in non-muscle actin. Protein chemical analysis involving thermolysin cleavage on [32P]ADP-ribosylated actin or tryptic digestion followed by a secondary thermolysin cleavage of the radiolabelled fragments showed one major site of ADP-ribosylation. From its amino acid composition and sequence, the radiolabelled peptide was identified as peptide 175-177, locating the acceptor ADP-ribosyl amino acid as Arg-177.

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Year:  1987        PMID： 2891567     DOI： 10.1016/0014-5793(87)81129-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  64 in total

1.  Clostridium perfringens iota-toxin: mapping of receptor binding and Ia docking domains on Ib.

Authors:  J C Marvaud; T Smith; M L Hale; M R Popoff; L A Smith; B G Stiles
Journal:  Infect Immun       Date:  2001-04       Impact factor: 3.441

2.  Binding component of Clostridium perfringens iota-toxin induces endocytosis in Vero cells.

Authors:  Masahiro Nagahama; Koichi Nagayasu; Keiko Kobayashi; Jun Sakurai
Journal:  Infect Immun       Date:  2002-04       Impact factor: 3.441

Review 3.  Targeting of the actin cytoskeleton by insecticidal toxins from Photorhabdus luminescens.

Authors:  Alexander E Lang; Gudula Schmidt; Joel J Sheets; Klaus Aktories
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-11-12       Impact factor: 3.000

Review 4.  Exploring the role of host cell chaperones/PPIases during cellular up-take of bacterial ADP-ribosylating toxins as basis for novel pharmacological strategies to protect mammalian cells against these virulence factors.

Authors:  Holger Barth
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-12-01       Impact factor: 3.000

Review 5.  Clostridial ADP-ribosyltransferases--modification of low molecular weight GTP-binding proteins and of actin by clostridial toxins.

Authors:  K Aktories
Journal:  Med Microbiol Immunol       Date:  1990       Impact factor: 3.402

6.  Production by Clostridium spiroforme of an iotalike toxin that possesses mono(ADP-ribosyl)transferase activity: identification of a novel class of ADP-ribosyltransferases.

Authors:  L L Simpson; B G Stiles; H Zepeda; T D Wilkins
Journal:  Infect Immun       Date:  1989-01       Impact factor: 3.441

Review 7.  Toxigenic clostridia.

Authors:  C L Hatheway
Journal:  Clin Microbiol Rev       Date:  1990-01       Impact factor: 26.132

Review 8.  Novel bacterial ADP-ribosylating toxins: structure and function.

Authors:  Nathan C Simon; Klaus Aktories; Joseph T Barbieri
Journal:  Nat Rev Microbiol       Date:  2014-07-14       Impact factor: 60.633

9.  Cytotoxic effects by microinjection of ADP-ribosylated skeletal muscle G-actin in PtK2 cells in the absence of Clostridium perfringens iota toxin.

Authors:  G Kiefer; M Lerner; P Sehr; I Just; K Aktories
Journal:  Med Microbiol Immunol       Date:  1996-02       Impact factor: 3.402

10.  ADP-ribosylation of Drosophila indirect-flight-muscle actin and arthrin by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin.

Authors:  I Just; E S Hennessey; D R Drummond; K Aktories; J C Sparrow
Journal:  Biochem J       Date:  1993-04-15       Impact factor: 3.857
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