Literature DB >> 2891520

Intranasal LH-RH treatment of cryptorchidism. A clinical trial and 5 years follow-up.

A Bertelsen1, J Thorup, P V Pedersen, K Mauritzen, N E Skakkebaek.   

Abstract

The effect of intranasal LH-RH on cryptorchidism was investigated in 45 prepubertal boys with 68 undescended testes. A daily dose of 1.2 mg LH-RH was given for 4 weeks. A total of 16 testes (24%) descended. Follow-up examination 5 years later showed that relapse had occurred in two cases. Fifty-two testes did not descend during the LH-RH treatment. However, seven of these testes descended spontaneously during puberty. So far surgical treatment has been carried out in 39 of the remaining 45 testes. Anatomical anomalies (ectopic position of the testis, open processus vaginalis, abnormal epididymis) explained the failure of LH-RH to cause descent in the majority of the surgically treated cases.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2891520     DOI： 10.1007/bf00452869

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN： 0340-6199            Impact factor:   3.183


  16 in total

1.  Luteinising hormone-releasing hormone nasal spray as therapy for undescended testicle.

Authors:  P Pirazzoli; F Zappulla; F Bernardi; M P Villa; D Aleksandrowicz; A Scandola; P Stancari; A Cicognani; E Cacciari
Journal:  Arch Dis Child       Date:  1978-03       Impact factor: 3.791

2.  Treatment of cryptorchidism with pernasal gonadotropin-releasing hormone therapy.

Authors:  J Happ; F Kollmann; C Krawehl; M Neubauer; U Krause; K Demisch; J Sandow; W Von Rechenberg; J Beyer
Journal:  Fertil Steril       Date:  1978-05       Impact factor: 7.329

3.  [4 years' experience with combined hormonal treatment of cryptorchism].

Authors:  F Hadziselimović; J Girard; B Herzog
Journal:  Z Kinderchir       Date:  1984-10

4.  The undescended testis: is there a role for LHRH?

Authors: 
Journal:  Lancet       Date:  1986-05-17       Impact factor: 79.321

5.  Luteinising hormone releasing hormone for incomplete descent of the testis.

Authors:  A M Klidjian; P G Swift; J M Johnstone
Journal:  Arch Dis Child       Date:  1985-06       Impact factor: 3.791

6.  Hormonal therapy of cryptorchidism. A randomized, double-blind study comparing human chorionic gonadotropin and gonadotropin-releasing hormone.

Authors:  J Rajfer; D J Handelsman; R S Swerdloff; R Hurwitz; H Kaplan; T Vandergast; R M Ehrlich
Journal:  N Engl J Med       Date:  1986-02-20       Impact factor: 91.245

7.  LHRH treatment in unilateral cryptorchidism: effect on testicular descent and hormonal response.

Authors:  B Karpe; P Eneroth; E M Ritzén
Journal:  J Pediatr       Date:  1983-12       Impact factor: 4.406

8.  Treatment of undescended testes with intranasal application of synthetic LH-RH.

Authors:  S Hagberg; O Westphal
Journal:  Eur J Pediatr       Date:  1982-12       Impact factor: 3.183

9.  Success, relapse and failure after intranasal LHRH treatment of cryptorchidism in 55 prepubertal boys.

Authors:  R Illig; H Bucher; A Prader
Journal:  Eur J Pediatr       Date:  1980-03       Impact factor: 3.183

10.  Double-blind, placebo-controlled study of luteinising-hormone-releasing-hormone nasal spray in treatment of undescended testes.

Authors:  S M deMuinck Keizer-Schrama; F W Hazebroek; A W Matroos; S L Drop; J C Molenaar; H K Visser
Journal:  Lancet       Date:  1986-04-19       Impact factor: 79.321
View more
  3 in total

Review 1.  A systematic review and meta-analysis of comparative studies assessing the efficacy of luteinizing hormone-releasing hormone therapy for children with cryptorchidism.

Authors:  Tao Li; Liang Gao; Peng Chen; Siyuan Bu; Dehong Cao; Lu Yang; Qiang Wei
Journal:  Int Urol Nephrol       Date:  2016-02-22       Impact factor: 2.370

2.  The influence of patency of the vaginal process on the efficacy of hormonal treatment of cryptorchidism.

Authors:  R Varela Cives; A Bautista Casasnovas; A Alonso Martin; M Pombo Arias; R Tojo Sierra
Journal:  Eur J Pediatr       Date:  1996-11       Impact factor: 3.183

3.  Effect of adjunctive hormonal therapy on testicular descent and spermatogenic function among children with cryptorchidism: a systematic review and meta-analysis.

Authors:  Kaiping Zhang; Yin Zhang; Min Chao
Journal:  Hormones (Athens)       Date:  2020-10-29       Impact factor: 2.885
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.