Literature DB >> 28914208

A Systematic Review of Clinical Studies Investigating Mesenchymal Stem Cells for Fracture Non-Union and Bone Defects.

Kieran Killington1, Reza Mafi2, Pouya Mafi2, Wasim S Khan3.   

Abstract

BACKGROUND: Fracture non-union is a significant problem with a wide range demographic and massive socioeconomic elements, as well as the clinical difficulties it presents. Conventional treatments with autograft and allograft bone grafting pose serious difficulties, thus, it is necessary to develop novel techniques with our ever increasing knowledge of bioengineering using natural materials.
OBJECTIVE: To search for current evidence regarding the treatment of fracture non-union or bone defects using mesenchymal stem cells (MSCs).
RESULTS: The results presented in this review show that the use of mesenchymal stem cells for the treatment of non-union and bone defects is optimistic. Several papers had positive outcomes to report. There is a need for higher level evidence.
CONCLUSION: A strong need of clinical results is required to further progress in cell therapy. Launched trials will hopefully provide this information in the near future. If clinical trials are positive, further development of complex tissue engineering techniques may be developed to treat large bone defects. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Bone defects; MSC; fracture non-union; mesenchymal stem cells; pseudoarthrosis; treatment; ununited fractures

Mesh：

Year:  2018        PMID： 28914208     DOI： 10.2174/1574888X12666170915121137

Source DB:  PubMed          Journal:  Curr Stem Cell Res Ther        ISSN： 1574-888X            Impact factor:   3.828


  9 in total

Review 1.  Therapeutic Efficacy and Safety of Osteoinductive Factors and Cellular Therapies for Long Bone Fractures and Non-Unions: A Meta-Analysis and Systematic Review.

Authors:  Angelos Kaspiris; Argyris C Hadjimichael; Elias S Vasiliadis; Dionysios J Papachristou; Peter V Giannoudis; Elias C Panagiotopoulos
Journal:  J Clin Med       Date:  2022-07-04       Impact factor: 4.964

2.  Engineered Cell-Secreted Extracellular Matrix Modulates Cell Spheroid Mechanosensing and Amplifies Their Response to Inductive Cues for the Formation of Mineralized Tissues.

Authors:  Tomas Gonzalez-Fernandez; Alejandro J Tenorio; Augustine M Saiz; J Kent Leach
Journal:  Adv Healthc Mater       Date:  2022-01-14       Impact factor: 11.092

3.  Allogenic Bone Graft Enriched by Periosteal Stem Cell and Growth Factors for Osteogenesis in Critical Size Bone Defect in Rabbit Model: Histopathological and Radiological Evaluation.

Authors:  Hadi Hassibi; Alireza Farsinejad; Shahriar Dabiri; Darioush Voosough; Abbas Mortezaeizadeh; Reza Kheirandish; Omid Azari
Journal:  Iran J Pathol       Date:  2020-04-21

4.  Systematic review assessing the evidence for the use of stem cells in fracture healing.

Authors:  Andrew Mott; Alex Mitchell; Catriona McDaid; Melissa Harden; Rachael Grupping; Alexandra Dean; Ailish Byrne; Laura Doherty; Hemant Sharma
Journal:  Bone Jt Open       Date:  2020-10-06

5.  A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering: The unsolved challenge.

Authors:  T Winkler; F A Sass; G N Duda; K Schmidt-Bleek
Journal:  Bone Joint Res       Date:  2018-05-05       Impact factor: 5.853

6.  The Adenosine A2A Receptor Agonist Accelerates Bone Healing and Adjusts Treg/Th17 Cell Balance through Interleukin 6.

Authors:  Xi Zheng; Dong Wang
Journal:  Biomed Res Int       Date:  2020-04-23       Impact factor: 3.411

7.  Influence of inflammatory conditions provided by macrophages on osteogenic ability of mesenchymal stem cells.

Authors:  Gema Vallés; Fátima Bensiamar; Leila Maestro-Paramio; Eduardo García-Rey; Nuria Vilaboa; Laura Saldaña
Journal:  Stem Cell Res Ther       Date:  2020-02-13       Impact factor: 6.832

8.  Influence of age on stem cells depends on the sex of the bone marrow donor.

Authors:  Michael Selle; Johanna Dorothea Koch; Alina Ongsiek; Linnea Ulbrich; Weikang Ye; Zhida Jiang; Christian Krettek; Claudia Neunaber; Sandra Noack
Journal:  J Cell Mol Med       Date:  2022-01-27       Impact factor: 5.310

9.  Strategy for the Generation of Engineered Bone Constructs Based on Umbilical Cord Mesenchymal Stromal Cells Expanded with Human Platelet Lysate.

Authors:  Ingrid Silva-Cote; Mónica Cruz-Barrera; Mariana Cañas-Arboleda; Luz Correa-Araujo; Leidi Méndez; Joanna Jagielska; Bernardo Camacho; Gustavo Salguero
Journal:  Stem Cells Int       Date:  2019-12-01       Impact factor: 5.443
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.