Literature DB >> 28913475

Anaesthesia in early childhood - is the development of the immature brain in danger?

Constantin Bodolea1.   

Abstract

Experimental studies performed on immature animal brains had demonstrated a neurotoxic effect following sedation and general anaesthetics administration. The same magnitude of neurotoxicity has been suggested but not been proven to neonates, infants and small children who have undergone anaesthesia. There is a justified and increasing inquiry regarding the administration of general anaesthesia to paediatric patients.

Entities:  

Keywords:  childhood; developing brain; general anaesthetics; neurotoxicity

Year:  2016        PMID: 28913475      PMCID: PMC5505361          DOI: 10.21454/rjaic.7518.231.chd

Source DB:  PubMed          Journal:  Rom J Anaesth Intensive Care        ISSN: 2392-7518


  60 in total

Review 1.  Neurotransmitters and apoptosis in the developing brain.

Authors:  C Ikonomidou; P Bittigau; C Koch; K Genz; F Hoerster; U Felderhoff-Mueser; T Tenkova; K Dikranian; J W Olney
Journal:  Biochem Pharmacol       Date:  2001-08-15       Impact factor: 5.858

Review 2.  Activity-dependent neuronal differentiation prior to synapse formation: the functions of calcium transients.

Authors:  Nicholas C Spitzer
Journal:  J Physiol Paris       Date:  2002 Jan-Mar

3.  Exposure to general anesthesia in early life and the risk of attention deficit/hyperactivity disorder development: a nationwide, retrospective matched-cohort study.

Authors:  Wen-Ru Ko; Yung-Po Liaw; Jing-Yang Huang; De-Hui Zhao; Hui-Chin Chang; Pei-Chieh Ko; Shiou-Rung Jan; Oswald Ndi Nfor; Yi-Chen Chiang; Long-Yau Lin
Journal:  Paediatr Anaesth       Date:  2014-03-10       Impact factor: 2.556

Review 4.  The uncomfortable reality … We simply do not know if general anesthesia negatively impacts the neurocognitive development of our small children.

Authors:  Glenn E Mann; Madelyn Kahana
Journal:  Int J Pediatr Otorhinolaryngol       Date:  2015-06-22       Impact factor: 1.675

5.  Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation.

Authors:  Matthew L Pearn; Yue Hu; Ingrid R Niesman; Hemal H Patel; John C Drummond; David M Roth; Katerina Akassoglou; Piyush M Patel; Brian P Head
Journal:  Anesthesiology       Date:  2012-02       Impact factor: 7.892

6.  Ketamine-induced neuroapoptosis in the fetal and neonatal rhesus macaque brain.

Authors:  Ansgar M Brambrink; Alex S Evers; Michael S Avidan; Nuri B Farber; Derek J Smith; Lauren D Martin; Gregory A Dissen; Catherine E Creeley; John W Olney
Journal:  Anesthesiology       Date:  2012-02       Impact factor: 7.892

7.  The effects of L-carnitine on the combination of, inhalation anesthetic-induced developmental, neuronal apoptosis in the rat frontal cortex.

Authors:  X Zou; N Sadovova; T A Patterson; R L Divine; C E Hotchkiss; S F Ali; J P Hanig; M G Paule; W Slikker; C Wang
Journal:  Neuroscience       Date:  2007-12-15       Impact factor: 3.590

8.  Increase of BDNF serum concentration in lithium treated patients with early Alzheimer's disease.

Authors:  Thomas Leyhe; Gerhard W Eschweiler; Elke Stransky; Thomas Gasser; Peter Annas; Hans Basun; Christoph Laske
Journal:  J Alzheimers Dis       Date:  2009       Impact factor: 4.472

9.  Isoflurane anesthesia induced persistent, progressive memory impairment, caused a loss of neural stem cells, and reduced neurogenesis in young, but not adult, rodents.

Authors:  Changlian Zhu; Jianfeng Gao; Niklas Karlsson; Qian Li; Yu Zhang; Zhiheng Huang; Hongfu Li; H Georg Kuhn; Klas Blomgren
Journal:  J Cereb Blood Flow Metab       Date:  2010-01-13       Impact factor: 6.200

10.  Characterization and quantification of isoflurane-induced developmental apoptotic cell death in mouse cerebral cortex.

Authors:  George K Istaphanous; Christopher G Ward; Xinyu Nan; Elizabeth A Hughes; John C McCann; John J McAuliffe; Steve C Danzer; Andreas W Loepke
Journal:  Anesth Analg       Date:  2013-03-04       Impact factor: 5.108

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  1 in total

Review 1.  Mitochondria May Mediate Prenatal Environmental Influences in Autism Spectrum Disorder.

Authors:  Richard E Frye; Janet Cakir; Shannon Rose; Raymond F Palmer; Christine Austin; Paul Curtin; Manish Arora
Journal:  J Pers Med       Date:  2021-03-18
  1 in total

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