Nasrin Zand1, Parvin Mansouri2, Mohsen Fateh3, Leila Ataie-Fashtami4, Samad Rezaee Khiabanloo5, Farid Safar5, Reza Chalangari6, Katalin Martits6, Afshan Shirkavand6. 1. Medical Laser Research Center (MLRC), Iranian Center for Medical Laser (ICML), Academic Center for Education, Culture and Research (ACECR), Tehran, Iran. 2. Skin and Stem Cell Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran. 3. Medical Laser Research Center (MLRC), ICML, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran. 4. Department of Regenerative Medicine, Royan Institute for Stem Cell Biology & Technology, Medical Laser Research Center (MLRC), Academic Center for Education, Culture and Research (ACECR), Tehran, Iran. 5. Imam Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran. 6. Laser and Plasma Institute, Shahid Beheshti University, Medical Physicist Researcher, Medical Laser Research Center (MLRC), Academic Center for Education, Culture and Research (ACECR), Tehran, Iran.
Abstract
Introduction: Pemphigus vulgaris (PV) is a chronic, serious autoimmune mucocutaneous bullous disease. Oral lesions in PV may be extremely painful. This pain may adversely affect the patients' oral intake and quality of life. This before-after clinical trial was designed to assess the pain relieving effects of single session of non-ablative, non-thermal CO2 laser therapy (NTCLT) in oral lesions of PV. Methods: Fifty painful oral lesions of fourteen patients with PV were illuminated by CO2 laser (power: 1 W, scanning the lesions with rapid circular motion of the handpiece) passing through a thick layer of transparent gel with high water content. The pain severity of the oral lesions was reported by the patients up to the fourth postoperative day. They were also asked to continue their existing systemic treatment during the course of this study as a precondition for the participation. Results: The severity of contact and non-stimulate (non-contact) pain declined immediately and significantly after NTCLT (P < 0.001). The pain relieving effect was sustained during the four successive days of follow-up. The procedure was pain free and no kind of analgesics was required. Following NTCLT, there were no visible thermal complications such as destruction, ablation or irritation of the oral lesions. Conclusion: The results of the trial proposed that single session of NTCLT could immediately and significantly relieve pain in oral lesions of PV, without any visible thermal complications.
Introduction: Pemphigus vulgaris (PV) is a chronic, serious autoimmune mucocutaneous bullous disease. Oral lesions in PV may be extremely painful. This pain may adversely affect the patients' oral intake and quality of life. This before-after clinical trial was designed to assess the pain relieving effects of single session of non-ablative, non-thermal CO2 laser therapy (NTCLT) in oral lesions of PV. Methods: Fifty painful oral lesions of fourteen patients with PV were illuminated by CO2 laser (power: 1 W, scanning the lesions with rapid circular motion of the handpiece) passing through a thick layer of transparent gel with high water content. The pain severity of the oral lesions was reported by the patients up to the fourth postoperative day. They were also asked to continue their existing systemic treatment during the course of this study as a precondition for the participation. Results: The severity of contact and non-stimulate (non-contact) pain declined immediately and significantly after NTCLT (P < 0.001). The pain relieving effect was sustained during the four successive days of follow-up. The procedure was pain free and no kind of analgesics was required. Following NTCLT, there were no visible thermal complications such as destruction, ablation or irritation of the oral lesions. Conclusion: The results of the trial proposed that single session of NTCLT could immediately and significantly relieve pain in oral lesions of PV, without any visible thermal complications.
Entities:
Keywords:
CO2 laser; LLLT; Laser phototherapy; NTCLT; Pemphigus vulgaris