Literature DB >> 28912617

Pulmonary hypertension: Clinical parameters of a difficult case in pregnancy.

Byron C Calhoun1.   

Abstract

Treatment of pulmonary hypertension in pregnancy with a prostacyclin analogue-iloprost and/or calcium channel antagonists appears to improve outcomes and survival. These medications could have been administered to the patient and the response monitored. If the patient did not respond to therapy, this patient may have had either a referral to or transfer to another high risk center with more experience in this type of pregnant patient. There is no literature to support termination of pregnancy improving maternal survival outcomes in these patients, even though termination is recommended by all obstetrical textbooks. Maternal survival, rather, appears to be related to response to therapy, type of therapy, and continuation of therapy.
SUMMARY: A patient who is pregnant with pulmonary hypertension (increased right-sided heart pressures) may be managed with medications. There is no literature to support termination of pregnancy improving maternal survival outcomes in patients with pulmonary hypertension, even though termination is recommended by all obstetrical textbooks. Maternal survival, rather, appears to be related to response to therapy, type of therapy, and continuation of therapy.

Entities:  

Keywords:  Pregnancy; Pulmonary hypertension

Year:  2017        PMID: 28912617      PMCID: PMC5592306          DOI: 10.1080/00243639.2016.1173812

Source DB:  PubMed          Journal:  Linacre Q        ISSN: 0024-3639


  14 in total

Review 1.  An evidence-based approach to the management of pulmonary arterial hypertension.

Authors:  Stephen L Archer; Evangelos D Michelakis
Journal:  Curr Opin Cardiol       Date:  2006-07       Impact factor: 2.161

2.  The use of iloprost in early pregnancy in patients with pulmonary arterial hypertension.

Authors:  C A Elliot; P Stewart; V J Webster; G H Mills; S P Hutchinson; E S Howarth; F A Bu'lock; R A Lawson; I J Armstrong; D G Kiely
Journal:  Eur Respir J       Date:  2005-07       Impact factor: 16.671

3.  Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension.

Authors:  T Gessler; T Schmehl; M M Hoeper; F Rose; H A Ghofrani; H Olschewski; F Grimminger; W Seeger
Journal:  Eur Respir J       Date:  2001-01       Impact factor: 16.671

4.  Inhaled iloprost to treat severe pulmonary hypertension. An uncontrolled trial. German PPH Study Group.

Authors:  H Olschewski; H A Ghofrani; T Schmehl; J Winkler; H Wilkens; M M Höper; J Behr; F X Kleber; W Seeger
Journal:  Ann Intern Med       Date:  2000-03-21       Impact factor: 25.391

5.  Improved survival in pregnancy and pulmonary hypertension using a multiprofessional approach.

Authors:  D G Kiely; R Condliffe; V Webster; G H Mills; I Wrench; S V Gandhi; K Selby; I J Armstrong; L Martin; E S Howarth; F A Bu'lock; P Stewart; C A Elliot
Journal:  BJOG       Date:  2010-04       Impact factor: 6.531

6.  Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide.

Authors:  Evangelos Michelakis; Wayne Tymchak; Dale Lien; Linda Webster; Kyoko Hashimoto; Stephen Archer
Journal:  Circulation       Date:  2002-05-21       Impact factor: 29.690

7.  The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension.

Authors:  S Rich; E Kaufmann; P S Levy
Journal:  N Engl J Med       Date:  1992-07-09       Impact factor: 91.245

Review 8.  Outcome of pulmonary vascular disease in pregnancy: a systematic overview from 1978 through 1996.

Authors:  B M Weiss; L Zemp; B Seifert; O M Hess
Journal:  J Am Coll Cardiol       Date:  1998-06       Impact factor: 24.094

9.  Management of pregnancy in women with pulmonary hypertension secondary to SLE and anti-phospholipid syndrome.

Authors:  E McMillan; W L Martin; J Waugh; I Rushton; M Lewis; T Clutton-Brock; J N Townend; M D Kilby; C Gordon
Journal:  Lupus       Date:  2002       Impact factor: 2.911

10.  Primary pulmonary hypertension. A national prospective study.

Authors:  S Rich; D R Dantzker; S M Ayres; E H Bergofsky; B H Brundage; K M Detre; A P Fishman; R M Goldring; B M Groves; S K Koerner
Journal:  Ann Intern Med       Date:  1987-08       Impact factor: 25.391

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  1 in total

1.  Targeting the Fetal Body and/or Mother-Child Connection: Vital Conflicts and Abortion.

Authors:  Helen Watt; Anthony McCarthy
Journal:  Linacre Q       Date:  2019-11-18
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