Katerina Hnatkova1, Lars Johannesen2, Jose Vicente3, Marek Malik4. 1. National Heart and Lung Institute, Imperial College, London, United Kingdom. 2. Division of Clinical Pharmacology I, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA. 3. Division of Cardiovascular and Renal Products, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA. 4. National Heart and Lung Institute, Imperial College, London, United Kingdom. Electronic address: marek.malik@btinternet.com.
Abstract
BACKGROUND: Little experience exists with the heart rate correction of J-Tpeak and Tpeak-Tend intervals. METHODS: In a population of 176 female and 176 male healthy subjects aged 32.3±9.8 and 33.1±8.4years, respectively, curve-linear and linear relationship to heart rate was investigated for different sections of the JT interval defined by the proportions of the area under the vector magnitude of the reconstructed 3D vectorcardiographic loop. RESULTS: The duration of the JT sub-section between approximately just before the T peak and almost the T end was found heart rate independent. Most of the JT heart rate dependency relates to the beginning of the interval. The duration of the terminal T wave tail is only weakly heart rate dependent. CONCLUSIONS: The Tpeak-Tend is only minimally heart rate dependent and in studies not showing substantial heart rate changes does not need to be heart rate corrected. For any correction formula that has linear additive properties, heart rate correction of JT and JTpeak intervals is practically the same as of the QT interval. However, this does not apply to the formulas in the form of Int/RRa since they do not have linear additive properties.
BACKGROUND: Little experience exists with the heart rate correction of J-Tpeak and Tpeak-Tend intervals. METHODS: In a population of 176 female and 176 male healthy subjects aged 32.3±9.8 and 33.1±8.4years, respectively, curve-linear and linear relationship to heart rate was investigated for different sections of the JT interval defined by the proportions of the area under the vector magnitude of the reconstructed 3D vectorcardiographic loop. RESULTS: The duration of the JT sub-section between approximately just before the T peak and almost the T end was found heart rate independent. Most of the JT heart rate dependency relates to the beginning of the interval. The duration of the terminal T wave tail is only weakly heart rate dependent. CONCLUSIONS: The Tpeak-Tend is only minimally heart rate dependent and in studies not showing substantial heart rate changes does not need to be heart rate corrected. For any correction formula that has linear additive properties, heart rate correction of JT and JTpeak intervals is practically the same as of the QT interval. However, this does not apply to the formulas in the form of Int/RRa since they do not have linear additive properties.
Authors: Fatima El-Hamad; Michal Javorka; Barbora Czippelova; Jana Krohova; Zuzana Turianikova; Alberto Porta; Mathias Baumert Journal: Med Biol Eng Comput Date: 2019-06-11 Impact factor: 2.602
Authors: Katerina Hnatkova; Jose Vicente; Lars Johannesen; Christine Garnett; David G Strauss; Norman Stockbridge; Marek Malik Journal: Front Physiol Date: 2019-07-25 Impact factor: 4.566
Authors: Irena Andršová; Katerina Hnatkova; Kateřina Helánová; Martina Šišáková; Tomáš Novotný; Petr Kala; Marek Malik Journal: Front Physiol Date: 2019-08-02 Impact factor: 4.566
Authors: Katerina Hnatkova; Jose Vicente; Lars Johannesen; Christine Garnett; David G Strauss; Norman Stockbridge; Marek Malik Journal: Sci Rep Date: 2019-10-21 Impact factor: 4.379
Authors: Irena Andršová; Katerina Hnatkova; Kateřina Helánová; Martina Šišáková; Tomáš Novotný; Petr Kala; Marek Malik Journal: BMC Pediatr Date: 2020-12-14 Impact factor: 2.125
Authors: Irena Andršová; Katerina Hnatkova; Martina Šišáková; Ondřej Toman; Peter Smetana; Katharina M Huster; Petra Barthel; Tomáš Novotný; Georg Schmidt; Marek Malik Journal: Sci Rep Date: 2021-07-12 Impact factor: 4.996
Authors: Marek Malik; Christine Garnett; Katerina Hnatkova; Jose Vicente; Lars Johannesen; Norman Stockbridge Journal: Drug Saf Date: 2019-03 Impact factor: 5.228
Authors: Katerina Hnatkova; Ondřej Toman; Martina Šišáková; Peter Smetana; Katharina M Huster; Petra Barthel; Tomáš Novotný; Georg Schmidt; Marek Malik Journal: Sci Rep Date: 2019-12-27 Impact factor: 4.379