Tero J W Pääkkö 1 , Reko J Renko 1 , Juha S Perkiömäki 1 , Y Antero Kesäniemi 1 , Antti S Ylitalo 2 , Jarmo A Lumme 1 , Heikki V Huikuri 1 , Heikki Ruskoaho 1 , Olli Vuolteenaho 1 , Olavi H Ukkola 1 Show Affiliations »
Abstract
BACKGROUND: Ambulatory blood pressure (ABP) has been shown to have an association with left ventricular diastolic dysfunction (LVDD) in cross-sectional assessments. We evaluated the association between ABP measurement (ABPM) and the development of LVDD during over 20 years of follow up in 414 middle-aged subjects from OPERA cohort. METHODS: ABPM, clinical, and anthropometric measurements were performed in baseline. Echocardiographic measurements were performed at baseline and during follow-up and E/E' ≥15 was considered indicating significant LVDD. RESULTS: Several baseline clinical characteristics (age, female gender, short stature, body mass index, prevalence of diabetes, in-office systolic BP (SBP), in-office pulse pressure (PP), N-terminal pro-atrial natriuretic peptide, and the use of antihypertensive therapy) were associated with the development of LVDD. Baseline 24-hour mean, daytime mean or nighttime mean SBP or diastolic BP were not associated with the development of LVDD, neither were different circadian BP profiles. Instead 24-hour mean, daytime mean and nighttime mean PP showed significant association with the development of LVDD (P from <0.001 to 0.001) even after adjustment with significant baseline clinical characteristics (P from 0.001 to 0.016). CONCLUSION: These findings suggest that ambulatory PP has an independent predictive value in the development of LVDD during over 20 years of follow-up. © American Journal of Hypertension, Ltd 2017. All rights reserved. For Permissions, please email: journals.permissions@oup.com
BACKGROUND: Ambulatory blood pressure (ABP) has been shown to have an association with left ventricular diastolic dysfunction (LVDD) in cross-sectional assessments. We evaluated the association between ABP measurement (ABPM) and the development of LVDD during over 20 years of follow up in 414 middle-aged subjects from OPERA cohort. METHODS: ABPM, clinical, and anthropometric measurements were performed in baseline. Echocardiographic measurements were performed at baseline and during follow-up and E/E' ≥15 was considered indicating significant LVDD. RESULTS: Several baseline clinical characteristics (age, female gender, short stature, body mass index, prevalence of diabetes , in-office systolic BP (SBP), in-office pulse pressure (PP), N-terminal pro-atrial natriuretic peptide, and the use of antihypertensive therapy) were associated with the development of LVDD. Baseline 24-hour mean, daytime mean or nighttime mean SBP or diastolic BP were not associated with the development of LVDD, neither were different circadian BP profiles. Instead 24-hour mean, daytime mean and nighttime mean PP showed significant association with the development of LVDD (P from <0.001 to 0.001) even after adjustment with significant baseline clinical characteristics (P from 0.001 to 0.016). CONCLUSION: These findings suggest that ambulatory PP has an independent predictive value in the development of LVDD during over 20 years of follow-up. © American Journal of Hypertension, Ltd 2017. All rights reserved. For Permissions, please email: journals.permissions@oup.com
Entities: Disease
Keywords:
ambulatory blood pressure; blood pressure; hypertension; left ventricular diastolic dysfunction; pulse pressure
Mesh： See more »
Year: 2017
PMID： 28911024 DOI： 10.1093/ajh/hpx087
Source DB: PubMed Journal: Am J Hypertens ISSN： 0895-7061 Impact factor: 2.689