Literature DB >> 28905052

Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants.

Cristina N Alexandru-Crivac1, Christian Umeobika2, Niina Leikoski3, Jouni Jokela3, Kirstie A Rickaby2, André M Grilo1, Peter Sjö4, Alleyn T Plowright5, Mohannad Idress1, Eike Siebs2, Ada Nneoyi-Egbe2, Matti Wahlsten3, Kaarina Sivonen3, Marcel Jaspars2, Laurent Trembleau2, David P Fewer3, Wael E Houssen6.   

Abstract

Macrocyclic peptides have promising therapeutic potential but the scaling up of their chemical synthesis is challenging. The cyanobactin macrocyclase PatGmac is an efficient tool for production but is limited to substrates containing 6-11 amino acids and at least one thiazoline or proline. Here we report a new cyanobactin macrocyclase that can cyclize longer peptide substrates and those not containing proline/thiazoline and thus allows exploring a wider chemical diversity.

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Year:  2017        PMID： 28905052     DOI： 10.1039/c7cc05913b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  Expanding the chemical space of synthetic cyclic peptides using a promiscuous macrocyclase from prenylagaramide biosynthesis.

Authors:  Snigdha Sarkar; Wenjia Gu; Eric W Schmidt
Journal:  ACS Catal       Date:  2020-06-17       Impact factor: 13.084

Review 2.  Parallel lives of symbionts and hosts: chemical mutualism in marine animals.

Authors:  Maho Morita; Eric W Schmidt
Journal:  Nat Prod Rep       Date:  2018-04-25       Impact factor: 13.423

3.  Amazonian Guarana- and Açai-Conjugated Extracts Improve Scratched Fibroblast Healing and Eisenia fetida Surgical Tail Amputation by Modulating Oxidative Metabolism.

Authors:  Fellipe D Felin; Ednea A Maia-Ribeiro; Carollina D Felin; Nathália A C Bonotto; Bárbara O Turra; Isabel Roggia; Verônica F Azzolin; Cibele F Teixeira; Moisés H Mastella; Carolina Rodrigues de Freitas; Jaqueline Greijanim; Daniel Santos; Erico M M Flores; Fernanda Barbisan; Ivana B M Cruz; Tiango A Ribeiro
Journal:  Oxid Med Cell Longev       Date:  2022-06-26       Impact factor: 7.310

Review 4.  The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis.

Authors:  Wenjia Gu; Shi-Hui Dong; Snigdha Sarkar; Satish K Nair; Eric W Schmidt
Journal:  Methods Enzymol       Date:  2018-05-04       Impact factor: 1.600

Review 5.  New developments in RiPP discovery, enzymology and engineering.

Authors:  Manuel Montalbán-López; Thomas A Scott; Sangeetha Ramesh; Imran R Rahman; Auke J van Heel; Jakob H Viel; Vahe Bandarian; Elke Dittmann; Olga Genilloud; Yuki Goto; María José Grande Burgos; Colin Hill; Seokhee Kim; Jesko Koehnke; John A Latham; A James Link; Beatriz Martínez; Satish K Nair; Yvain Nicolet; Sylvie Rebuffat; Hans-Georg Sahl; Dipti Sareen; Eric W Schmidt; Lutz Schmitt; Konstantin Severinov; Roderich D Süssmuth; Andrew W Truman; Huan Wang; Jing-Ke Weng; Gilles P van Wezel; Qi Zhang; Jin Zhong; Jörn Piel; Douglas A Mitchell; Oscar P Kuipers; Wilfred A van der Donk
Journal:  Nat Prod Rep       Date:  2020-09-16       Impact factor: 15.111

Review 6.  Possible Functional Roles of Patellamides in the Ascidian-Prochloron Symbiosis.

Authors:  Philipp Baur; Michael Kühl; Peter Comba; Lars Behrendt
Journal:  Mar Drugs       Date:  2022-02-02       Impact factor: 5.118
  6 in total

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