Literature DB >> 28903060

Effects of curcumin and curcumin analogues on TRP channels.

Marianna Nalli1, Giorgio Ortar2, Aniello Schiano Moriello3, Vincenzo Di Marzo3, Luciano De Petrocellis4.   

Abstract

A series of 33 curcumin analogues was synthesized and tested on TRPA1, TRPM8, and TRPV1 channels. Twenty of them acted as good modulators of TRPA1 channels. None was able to significantly activate TRPM8 channels, while curcumin itself and six curcuminoids belonging to the 1,3-dicarbonyl and acyclic series behaved as 'true' antagonists with IC50 values<5μM. Only few curcuminoids were able to modulate TRPV1 channels with EC50 and IC50 values ranging from 3.4 and 6.0μM.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Curcumin; Curcuminoids; TRP channels; TRPA1; TRPM8; TRPV1

Mesh：

Substances：

Year:  2017        PMID： 28903060     DOI： 10.1016/j.fitote.2017.09.007

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


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