Hamid Reza Khorshidi1, Amir Kasraianfard2, Amir Derakhshanfar3, Siavash Rahimi4, Ali Sharifi5, Hamid Reza Makarchian6, Manoochehr Ghorbanpoor7, Seyed Mohammad Reza Javadi5. 1. Assistant Professor, Department of Surgery, Medical Sciences, Hamadan University, Iran. Scientific and intellectual content of the study, Conception and design of the study, critical revision. 2. MD, Resident, Department of Surgery, Medical Sciences, Hamadan University, Iran. Technical procedures, manuscript writing. 3. Associate Professor, Department of Surgery, Medical Sciences, Hamadan University, Iran. Conception and design of the study, critical revision. 4. MD degree, Faculty of Medicine, Medical Sciences, Mazandaran University, Sari, Iran. Acquisition of data, manuscript preparation. 5. Assistant Professor, Department of Surgery, Medical Sciences, Hamadan University, Iran. Critical revision, final approval. 6. Assistant Professor, Department of Surgery, Medical Sciences, Hamadan University, Iran. Statistics analysis, manuscript preparation. 7. Assistant Professor, Department of Surgery, Medical Sciences, Hamadan University, Iran. Analysis and interpretation of data, technical procedures.
Abstract
PURPOSE: : To evaluate the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing of postoperative surgical adhesion formation. METHODS: : Forty male Wistar rats were randomly assigned into five groups with eight rats in each group including control, hyaluronate, sesame, honey and silver groups. After two weeks the animals underwent laparotomy and were evaluated by two different blinded surgeons for severity of adhesions based on the two different classification scoring systems including Nair classification and cumulative adhesion scoring scale. RESULTS: : The scores of severity of adhesions in the hyaluronate and sesame groups were significantly lower than the control group based on the Nair classification (both P-values = 0.02), however based on the cumulative adhesion scoring scale just the score of severity of adhesions in the hyaluronate group was significantly lower than the control group (P-value = 0.02). In the hyaluronate group the severity of adhesions was decreased by 48% based on the cumulative adhesion scoring scale. CONCLUSIONS: : Sodium hyaluronate and sesame oil may have a significant effect in preventing postoperative surgical adhesion formation.
PURPOSE: : To evaluate the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing of postoperative surgical adhesion formation. METHODS: : Forty male Wistar rats were randomly assigned into five groups with eight rats in each group including control, hyaluronate, sesame, honey and silver groups. After two weeks the animals underwent laparotomy and were evaluated by two different blinded surgeons for severity of adhesions based on the two different classification scoring systems including Nair classification and cumulative adhesion scoring scale. RESULTS: : The scores of severity of adhesions in the hyaluronate and sesame groups were significantly lower than the control group based on the Nair classification (both P-values = 0.02), however based on the cumulative adhesion scoring scale just the score of severity of adhesions in the hyaluronate group was significantly lower than the control group (P-value = 0.02). In the hyaluronate group the severity of adhesions was decreased by 48% based on the cumulative adhesion scoring scale. CONCLUSIONS: : Sodium hyaluronate and sesame oil may have a significant effect in preventing postoperative surgical adhesion formation.
Authors: Aditi Swarup; Abigail K Grosskopf; Lindsay M Stapleton; Varun R Subramaniam; BaoXiang Li; Irving L Weissman; Eric A Appel; Albert Y Wu Journal: Transl Vis Sci Technol Date: 2022-02-01 Impact factor: 3.283