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Literature DB >> 28902921

Correction: CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo.

Abstract

[This corrects the article DOI: 10.1371/journal.ppat.1006509.].

Entities: Gene Species

Year: 2017 PMID： 28902921 PMCID： PMC5597225 DOI： 10.1371/journal.ppat.1006617

Source DB: PubMed Journal: PLoS Pathog ISSN： 1553-7366 Impact factor: 6.823

There are two errors in Table 3. The purity values (98, 98) should be listed below donor ID 409000. In addition, in the first column of the 409000 donor ID row, the third line should read 1*. The publisher apologizes for the errors.

Table 3

Analysis of env amplicons isolated from HIV+ donors.

Donor ID(% purity)(S1, S2)	HSPC Sort 1 (S1)env amplicons				HSPC Sort 2 (S2)env amplicons				PBMCenv amplicons
Donor ID(% purity)(S1, S2)	#	FPR	Geno^b	Pheno^c	#	FPR	Geno	Pheno	#	FPR	Geno
409000(98, 98)	1**w1*w1	610.70.7	R5X4/DualX4/Dual		ND				1711	38–610.7	R5X4/Dual
413402(94, 91)	1*	1.7	X4/Dual	Dual	ND				6	1.7	X4/Dual
414000(95, 85)	1*	57	R5	R5	ND				5	57	R5
415000(95, NA)	1**	71	R5	R5	NA				20	43–83	R5
419000(95, NA)	1***	89	R5		NA				21	22–99	R5
420000(99, 92)	1**1w11**w	19730.78.1	R5R5X4/DualX4/Dual	R5Dual	ND				117	14–730.5–1.7	R5X4/Dual
421000(99, 96)	1*w2*	7.87.4,7.8	X4/DualX4/Dual	X4	1**w	7.8	X4/Dual		45	24–944.7–9.6	R5X4/Dual
426000(97, 92)	ND				4**2w1**w	29–6020–314.8	R5R5X4/Dual		101	20–383.2	R5X4/Dual
428408(95, 86)(91, 91)	2**1**	83,841.3	R5X4/Dual		1**w	1.3	X4/Dual		2216	30–1000.7–6.8	R5X4/Dual
431000(93, 89)	2**1**	7579	R5R5	R5R5	ND				8	38–90	R5
432000(98, 99)	1**1**	172.8	R5X4/Dual	X4	1**1**	2.83.4	X4/DualX4/Dual	NF	181114	493.4–8.5742.8–4.73.4–8.5	R5X4/DualR5X4/DualX4/Dual
434423(92, 89)(94, 84)	1**	38	R5		1**	46	R5		18	38–82	R5
435412406(99, 99)(98, 83)(95, 94)	1211**w	83878945	R5R5R5R5	R5R5R5	1**	83	R5	R5	103	42–99	R5
436000(93, 85)	ND				2**	31	R5	R5	8	31–85	R5
437000(94, 92)	1**	55	R5				ND		8	12–55	R5
449000(90, 95)	1*	100	R5		1**	81	R5		5	59–99	R5
453000(96, 83)	ND				1***	74	R5	R5	6	41–86	R5
454304(92,93)	ND				11w	319.6	R5X4/Dual		241	11–976.8	R5X4/Dual
456000(93,90)	ND				3***	13–39	R5		102	10.5–39 7.4, 9.2	R5X4/Dual

# indicates the number of amplicons of that type isolated from each donor.

bgenotypic prediction of co-receptor usage by Geno2pheno using a false positive rate (FPR) cutoff of _10% [36, 37].

cphenotypic analysis of co-receptor usage (see Table 4).

“w” indicates amplicons from whole genome PCR and black text indicates amplicons from multiplex PCR reaction.

Asterisks reflect the likelihood that CD3+ T cells contamination was responsible for the amplicon

*p < 0.05 by (1) only

**p < .05 by (1) and (2)

***p < .01 by (1) and (2)

****p < .001 by (1) and (2) where (2) is using the more conservative assessment (Fig 2) [10].

Abbreviations: HSPC, hematopoietic stem and progenitor cells; PBMC, peripheral blood mononuclear cells; NA, not analyzed due to purity concerns; R5, CCR5; X4, CXCR4; ND, not detectable; NF, non-functional.

Each set of three non-zero numbers in the donor name represents an independent donation.

# indicates the number of amplicons of that type isolated from each donor. bgenotypic prediction of co-receptor usage by Geno2pheno using a false positive rate (FPR) cutoff of _10% [36, 37]. cphenotypic analysis of co-receptor usage (see Table 4). “w” indicates amplicons from whole genome PCR and black text indicates amplicons from multiplex PCR reaction. Asterisks reflect the likelihood that CD3+ T cells contamination was responsible for the amplicon *p < 0.05 by (1) only **p < .05 by (1) and (2) ***p < .01 by (1) and (2) ****p < .001 by (1) and (2) where (2) is using the more conservative assessment (Fig 2) [10]. Abbreviations: HSPC, hematopoietic stem and progenitor cells; PBMC, peripheral blood mononuclear cells; NA, not analyzed due to purity concerns; R5, CCR5; X4, CXCR4; ND, not detectable; NF, non-functional. Each set of three non-zero numbers in the donor name represents an independent donation.

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1. CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo.

Authors: Nadia T Sebastian; Thomas D Zaikos; Valeri Terry; Frances Taschuk; Lucy A McNamara; Adewunmi Onafuwa-Nuga; Ryan Yucha; Robert A J Signer; James Riddell; Dale Bixby; Norman Markowitz; Sean J Morrison; Kathleen L Collins
Journal: PLoS Pathog Date: 2017-07-21 Impact factor: 6.823

1 in total