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Literature DB >> 28902599

The Potential Role of Inhibitory Receptors in the Treatment of Psoriasis.

Neha Shah, Sabina Sandigursky, Adam Mor.

Abstract

Psoriasis is a common autoimmune disorder that affects the skin. Approximately 30% of individuals with psoriasis will develop inflammatory arthritis, often in the setting of human leukocyte antigen B27. Both forms of disease are thought to be the result of prolonged inflammation mediated by T lymphocytes, dendritic cells, and keratinocytes. While there are treatments aimed at immunomodulation, targeting T cell co-inhibitory receptors signaling pathways may provide therapeutic benefit. This review will discuss in detail four T cell co-inhibitory receptors and their potential application for the treatment of psoriasis and psoriatic arthritis.

Entities: Chemical Disease Gene Mutation Species

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Year: 2017 PMID： 28902599 PMCID： PMC7010333

Source DB: PubMed Journal: Bull Hosp Jt Dis (2013) ISSN： 2328-4633

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References

78 in total

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The Potential Role of Inhibitory Receptors in the Treatment of Psoriasis.

1. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength.

2. Inhibition of pro-inflammatory cytokine generation by CTLA4-Ig in the skin and colon of mice adoptively transplanted with CD45RBhi CD4+ T cells correlates with suppression of psoriasis and colitis.

Review 3. Psoriatic arthritis: current therapy and future directions.

4. Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity.

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Review 7. The CD4-like molecule LAG-3, biology and therapeutic applications.

8. T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor.

Review 9. Tim-3 and Tim-4 as the potential targets for antitumor therapy.

10. Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells.