| Literature DB >> 2890215 |
J S Chamberlain1, S G Grant, A A Reeves, L J Mullins, D A Stephenson, E P Hoffman, A P Monaco, L M Kunkel, C T Caskey, V M Chapman.
Abstract
The murine locus corresponding to the human Duchenne/Becker muscular dystrophy (DMD) gene has been regionally mapped on the mouse X chromosome by hybridizing DNA from interspecies mouse crosses with a cDNA clone for the mouse Dmd gene. The results demonstrate that the relative organization of genes on the murine and human X chromosomes is more divergent than has previously been postulated. Furthermore, the mouse Dmd gene maps to a similar region of the X chromosome as does the mouse muscular dystrophy mutation mdx, providing further evidence that the mdx mutant may be a murine equivalent of human DMD. However, Southern analysis of portions of the mouse Dmd gene has not yet revealed any differences between mdx and wild-type mice.Entities:
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Year: 1987 PMID： 2890215 DOI： 10.1007/bf01534487
Source DB: PubMed Journal: Somat Cell Mol Genet ISSN： 0740-7750