Literature DB >> 28901853

Synthesis of New Bis-Spiropyrazoles as Antitumor Agents under Ultrasound Irradiation.

Naglaa A Abdel Hafez1, Huwaida M E Hassaneen2, Thoraya A Farghaly2,3, Sayed M Riyadh2,4, Heba S A Elzahabi5.   

Abstract

OBJECTIVE AND
BACKGROUND: Hydrazonoyl halides were used as precursors for the synthesis of a new series of bis-spiropyrazoles via reaction with 3,5-diarylidene-piperidone derivatives under ultrasound irradiation. The products were secluded in good yield after short reaction periods.
CONCLUSION: The anticancer activity of bis-spiropyrazoles against HepG2 (hepatic cancer), A549 (lung cancer) and CaCo2 (colon cancer) cell lines was screened. Three tested compounds 4b, 4c and 4f showed promising activity. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  3; 5-diarylidene-piperidones; Antitumor activity; Bis-spiropyrazoles; hydrazonoyl halides; spiropiperidinecarbinols; ultrasound irradiation.

Mesh：

Substances：

Year:  2018        PMID： 28901853     DOI： 10.2174/1389557517666170912170027

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  2 in total

1.  Synthesis, DFT Molecular Geometry and Anticancer Activity of Symmetrical 2,2'-(2-Oxo-1H-benzo[d]imidazole-1,3(2H)-diyl) Diacetate and Its Arylideneacetohydrazide Derivatives.

Authors:  Manel Dhahri; Firdos Alam Khan; Abdul-Hamid Emwas; Rua B Alnoman; Mariusz Jaremko; Nadjet Rezki; Mohamed Reda Aouad; Mohamed Hagar
Journal:  Materials (Basel)       Date:  2022-03-30       Impact factor: 3.623

2.  Synthesis of Chitosan-La2O3 Nanocomposite and Its Utility as a Powerful Catalyst in the Synthesis of Pyridines and Pyrazoles.

Authors:  Khaled D Khalil; Sayed M Riyadh; Mariusz Jaremko; Thoraya A Farghaly; Mohamed Hagar
Journal:  Molecules       Date:  2021-06-17       Impact factor: 4.411
  2 in total

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