Jiaqiang Wang 1,2 , Chien-Shan Cheng 2,3 , Yan Lu 1,2 , Xiaowei Ding 1,2 , Minmin Zhu 1,2 , Changhong Miao 1,2 , Jiawei Chen 1,2 Show Affiliations »
Abstract
BACKGROUND: Propofol, a widely used intravenous anesthetic agent, is traditionally applied for sedation and general anesthesia. Explanation: Recent attention has been drawn to explore the effect and mechanisms of propofol against cancer progression in vitro and in vivo. Specifically, the proliferation-inhibiting and apoptosis-inducing properties of propofol in cancer have been studied. However, the underlying mechanisms remain unclear. CONCLUSION: This review focused on the findings within the past ten years and aimed to provide a general overview of propofol's malignance-modulating properties and the potential molecular mechanisms. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: Propofol , a widely used intravenous anesthetic agent, is traditionally applied for sedation and general anesthesia. Explanation: Recent attention has been drawn to explore the effect and mechanisms of propofol against cancer progression in vitro and in vivo. Specifically, the proliferation-inhibiting and apoptosis-inducing properties of propofol in cancer have been studied. However, the underlying mechanisms remain unclear. CONCLUSION: This review focused on the findings within the past ten years and aimed to provide a general overview of propofol 's malignance-modulating properties and the potential molecular mechanisms. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Chemical
Disease
Keywords:
Propofol; anesthetic; anti-cancer; general anesthesia; malignance-modulating; neoplasms.
Mesh： See more »
Substances： See more »
Year: 2018
PMID： 28901262 DOI： 10.2174/1871520617666170912120327
Source DB: PubMed Journal: Anticancer Agents Med Chem ISSN： 1871-5206 Impact factor: 2.505